User profiles for E. Josephs

Emily B. Josephs

- Verified email at msu.edu - Cited by 1240

Eric Josephs

- Verified email at uncg.edu - Cited by 875

Local adaptation: causal agents of selection and adaptive trait divergence

…, ML DeMarche, EB Josephs… - Annual review of …, 2022 - annualreviews.org
… ; (c) the agents of selection underlying local adaptation, when field experiments are paired
with environmental manipulations; (d) the processes that constrain local adaptation; and (e) …

Genotype–environment associations to reveal the molecular basis of environmental adaptation

JR Lasky, EB Josephs, GP Morris - The Plant Cell, 2023 - academic.oup.com
A fundamental goal in plant biology is to identify and understand the variation underlying
plants’ adaptation to their environment. Climate change has given new urgency to this goal, as …

[HTML][HTML] The important contribution of transposable elements to phenotypic variation and evolution

NS Catlin, EB Josephs - Current opinion in plant biology, 2022 - Elsevier
Transposable elements (TEs) are responsible for significant genomic variation in plants.
Our understanding of the evolutionary forces shaping TE polymorphism has lagged behind …

Increasing the specificity of CRISPR systems with engineered RNA secondary structures

DD Kocak, EA Josephs, V Bhandarkar, SS Adkar… - Nature …, 2019 - nature.com
e–h, Predicted structure of optimized hp-sgRNA spacers (hairpin 1 (e), hairpin 3 (f), hairpin
1 (g), hairpin 4 (h)); arrows indicate 3′ end of RNA. The sequences of the sgRNA variants …

Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage

EA Josephs, DD Kocak, CJ Fitzgibbon… - Nucleic acids …, 2015 - academic.oup.com
CRISPR-associated endonuclease Cas9 cuts DNA at variable target sites designated by a
Cas9-bound RNA molecule. Cas9's ability to be directed by single ‘guide RNA’ molecules to …

Hybrid origins and the earliest stages of diploidization in the highly successful recent polyploid Capsella bursa-pastoris

…, A Salcedo, K Holm, EB Josephs… - Proceedings of the …, 2015 - National Acad Sciences
… orientalis (4,000) but much smaller than the N e of the highly outcrossing C. grandiflora (…
that the N e of the founding population may be as large as 40,000. The reductions in N e in C. …

[HTML][HTML] Co-Variation between Seed Dormancy, Growth Rate and Flowering Time Changes with Latitude in Arabidopsis thaliana

…, C Tang, B Stich, T Sikosek, S Effgen, E Josephs… - PloS one, 2013 - journals.plos.org
Life-history traits controlling the duration and timing of developmental phases in the life
cycle jointly determine fitness. Therefore, life-history traits studied in isolation provide an …

[HTML][HTML] Evidence for Widespread Positive and Negative Selection in Coding and Conserved Noncoding Regions of Capsella grandiflora

RJ Williamson, EB Josephs, AE Platts… - PLoS …, 2014 - journals.plos.org
The extent that both positive and negative selection vary across different portions of plant
genomes remains poorly understood. Here, we sequence whole genomes of 13 Capsella …

What can genome‐wide association studies tell us about the evolutionary forces maintaining genetic variation for quantitative traits?

EB Josephs, JR Stinchcombe, SI Wright - New Phytologist, 2017 - Wiley Online Library
Understanding the evolutionary forces that shape genetic variation within species has long
been a goal of evolutionary biology. Integrating data for the genetic architecture of traits from …

Association mapping reveals the role of purifying selection in the maintenance of genomic variation in gene expression

EB Josephs, YW Lee… - Proceedings of the …, 2015 - National Acad Sciences
… As might be expected from its large effective population size (N e ) and relative lack of
population structure, purifying and positive selection are prevalent in C. grandiflora (4, 27), making …