The transport of ions across the membranes of cells and organelles is a prerequisite for
many of life's processes. Transport often involves very precise selectivity for specific ions. …

… & Gouaux, E. A competitive inhibitor traps LeuT in an open-to-out conformation. Science
322… & Gouaux, E. Antidepressant binding site in a bacterial homologue of neurotransmitter …

… e Sequence of the amino terminal 6 residues of the mature protein, after cleavage of the
signal sequence. Sequences marked with an asterisk have been determined by N-terminal …

… Kawate for sharing the FSEC screening protocol, Gouaux laboratory members and E.
McCleskey for discussions. We also thank the personnel at beamlines 8.2.1 and 8.2.2 of the …

Na + /Cl - -dependent transporters terminate synaptic transmission by using electrochemical
gradients to drive the uptake of neurotransmitters, including the biogenic amines, from the …

Fast inhibitory neurotransmission is essential for nervous system function and is mediated by
binding of inhibitory neurotransmitters to receptors of the Cys-loop family embedded in the …

… e–g, SDS–PAGE analysis of spontaneous crosslinking of cysteines introduced at intersubunit
interfaces. … e, M3 residues forming the narrowest portion of the ion conduction pathway. …

The family of hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels are
crucial for a range of electrical signalling, including cardiac and neuronal pacemaker activity, …

… of four subsites (D, E, F, and G in Figure 3D). Subsites D and E are located at the base of …
with the hydrogen bond donors in subsites D and E nearly identically (Figure 3B). The main …

… c–e, Magnified view of the interactions at sites I, II and III. Dashed lines indicate hydrogen
bonds or salt bridges. The interacting residues from NR1 and NR2A are coloured white and …