While immune responses in neurodegeneration were regarded as little more than a curiosity
a decade ago, they are now increasingly moving toward center stage. Factors driving this …

… Using a human-derived NTERA cell line expressing enhanced (e)GFP under the Dcx
promoter, we assayed neural differentiation and observed a significant decrease in eGFP …

… S3E), which was performed by YY under the supervision of MC, and the phagocytosis
assay with latex beads, which was carried out by E. Czirr under the supervision of TW-CFM …

Phagocytosis controls CNS homeostasis by facilitating the removal of unwanted cellular
debris. Accordingly, impairments in different receptors or proteins involved in phagocytosis …

… Quantification of synaptophysin immunoreactivity (D), and calbindin immunoreactivity (E),
in the molecular layer of the dentate gyrus of old male parabionts; WT isochronic (n = 6), APP …

… 5, D and E). To measure the half-life of Aβ, its production was stopped with the γ-secretase
inhibitor Compound E, revealing that the rate of concentration decline was significantly …

… 1E), were not different between 3-week postfracture mice and controls. … cells; (D) CD19+/B
cells as percentage of total lymphocytes; (E) CD19+CD20-CD27+/plasmablasts; (F) CD20+/ B …

… Constructs were transformed into E. coli BL21 and protein expression induced by addition
of IPTG (isopropyl β-D-thiogalactoside). Bacteria were lysed by sonification and freezing. …

… Eva Czirr… Eva Czirr … (e) Treatment of the cells used in D with the γ-secretase inhibitor
DAPT was carried out and the levels of APP-C99 and APP-C83 were examined. …

Proteolytic processing of the amyloid precursor protein by β- and γ-secretase generates the
amyloid-β (Aβ) peptides, which are principal drug targets in Alzheimer disease therapeutics. …