User profiles for E. Castren

Eero Castrén

Neuroscience Center, University of Helsinki, Finland
Verified email at helsinki.fi
Cited by 26591

The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity

E Castrén, T Rantamäki - Developmental neurobiology, 2010 - Wiley Online Library
… O’Leary OF, Wu X, Castren E. 2009. Chronic fluoxetine treatment increases expression of
synaptic proteins in the hippocampus of the ovariectomized rat: Role of BDNF signalling. …

Role of neurotrophic factors in depression

E Castrén, V Võikar, T Rantamäki - Current opinion in pharmacology, 2007 - Elsevier
… signal-regulated kinase pathway, but does activate phospholipase-Cγ signaling and lead
to the phosphorylation of cAMP-related element binding protein (Rantamäki and Castrén, …

Serotonin and neuroplasticity–links between molecular, functional and structural pathophysiology in depression

C Kraus, E Castrén, S Kasper… - … & Biobehavioral Reviews, 2017 - Elsevier
… Single studies one antidepressant response are contradictory (Castren and Kojima, 2016), …
E. Castén reports no potential conflict of interest. The research was part of the thesis work of …

Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects

…, H Nawa, R Aloyz, P Ernfors, E Castrén - Journal of …, 2003 - Soc Neuroscience
Recent studies have indicated that exogenously administered neurotrophins produce
antidepressant-like behavioral effects. We have here investigated the role of endogenous brain-…

The antidepressant fluoxetine restores plasticity in the adult visual cortex

…, L Baroncelli, R De Pasquale, O F. O'Leary, E Castren… - Science, 2008 - science.org
We investigated whether fluoxetine, a widely prescribed medication for treatment of depression,
restores neuronal plasticity in the adult visual system of the rat. We found that chronic …

Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate …

…, G Lucas, P Ernfors, M Castrén, E Castrén - Journal of …, 2005 - Soc Neuroscience
Antidepressants increase proliferation of neuronal progenitor cells and expression of brain-derived
neurotrophic factor (BDNF) in the hippocampus. We investigated the role of BDNF …

Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth …

F Zafra, E Castren, H Thoenen… - Proceedings of the …, 1991 - National Acad Sciences
In the central nervous system brain-derived neurotrophic factor (BDNF) and nerve growth
factor (NGF) are predominantly located in neurons. Here we demonstrate that the balance …

Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.

E Castren, F Zafra, H Thoenen… - Proceedings of the …, 1992 - National Acad Sciences
Specific sensory input has profound transient and long-lasting effects on the function of
corresponding sensory cortical areas both during development and in adulthood. To study …

Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes

F Zafra, D Lindholm, E Castren, J Hartikka… - Journal of …, 1992 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) and NGF are both expressed by neurons in the
hippocampus. In previous studies, it has been demonstrated that both BDNF and NGF mRNA …

Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation

D Lindholm, E Castren, R Kiefer, F Zafra… - The Journal of cell …, 1992 - rupress.org
E. Castrén is supported by a scholarship fromAlexander von Humboldt Stiftung. F. Zafra is
arecipient ofa fellowship fromthe … Meyer, MJ Radeke, TP Misko, E. Shooter, and H . Thoenen . …