User profiles for E. Bushell

Ellen Bushell

Group Leader Umeċ University
Verified email at umu.se
Cited by 2359

[PDF][PDF] Functional profiling of a Plasmodium genome reveals an abundance of essential genes

E Bushell, AR Gomes, T Sanderson, B Anar, G Girling… - Cell, 2017 - cell.com
The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium

…, TD Otto, C Pfander, NJ Dickens, AA Religa, E Bushell… - Nature, 2014 - nature.com
Commitment to and completion of sexual development are essential for malaria parasites (protists
of the genus Plasmodium) to be transmitted through mosquitoes 1 . The molecular …

[PDF][PDF] A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite

AR Gomes, E Bushell, F Schwach, G Girling, B Anar… - Cell host & …, 2015 - cell.com
… renders Plasmodium DNA difficult to engineer in E. coli. A malaria parasite of rodents, P. …
berghei genomic DNA (gDNA) can be propagated efficiently in E. coli as large genomic inserts …

Reverse genetics screen identifies six proteins important for malaria development in the mosquito

A Ecker, ESC Bushell, R Tewari… - Molecular …, 2008 - Wiley Online Library
Transmission from the vertebrate host to the mosquito vector represents a major population
bottleneck in the malaria life cycle that can successfully be targeted by intervention strategies…

CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact

…, MS Paoletta, T Sanderson, ESC Bushell - Biochemical Society …, 2022 - portlandpress.com
… Nonetheless, >2 kb Plasmodium DNA fragments are difficult to clone and stably maintain in
E. coli, and scaling up restriction-ligation cloning is impractical. The challenges of generating …

PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites

F Schwach, E Bushell, AR Gomes, B Anar… - Nucleic acids …, 2015 - academic.oup.com
… berghei genomic DNA unstable in E. coli. The latter problem can be overcome in part by …
berghei genes in their entirety to be maintained in E. coli for the first time (3). We have recently …

[PDF][PDF] Genome-scale identification of essential metabolic processes for targeting the Plasmodium liver stage

RR Stanway, E Bushell, A Chiappino-Pepe, M Roques… - Cell, 2019 - cell.com
Plasmodium gene functions in mosquito and liver stages remain poorly characterized due
to limitations in the throughput of phenotyping at these stages. To fill this gap, we followed …

Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals

…, S Gandon, KP Patra, C Herd, E Bushell… - Genome …, 2018 - genome.cshlp.org
… There are two additional novel gene families in the avian malaria genomes fam-e and
fam-i. Fam-e is present in both avian malaria species and is a two-exon gene with an average …

Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi …

…, F Schwach, M Brochet, E Bushell… - Genes & …, 2013 - genesdev.cshlp.org
Fertilization is a crucial yet poorly characterized event in eukaryotes. Our previous discovery
that the broadly conserved protein HAP2 (GCS1) functioned in gamete membrane fusion in …

Global analysis of apicomplexan protein S‐acyl transferases reveals an enzyme essential for invasion

K Frénal, CL Tay, C Mueller, ES Bushell, Y Jia… - Traffic, 2013 - Wiley Online Library
The advent of techniques to study palmitoylation on a whole proteome scale has revealed
that it is an important reversible modification that plays a role in regulating multiple biological …