User profiles for E. Bushell
Ellen BushellGroup Leader Umeċ University Verified email at umu.se Cited by 2359 |
[PDF][PDF] Functional profiling of a Plasmodium genome reveals an abundance of essential genes
The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …
development through the identification of essential genes and pathways, we have measured …
A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium
Commitment to and completion of sexual development are essential for malaria parasites (protists
of the genus Plasmodium) to be transmitted through mosquitoes 1 . The molecular …
of the genus Plasmodium) to be transmitted through mosquitoes 1 . The molecular …
[PDF][PDF] A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite
… renders Plasmodium DNA difficult to engineer in E. coli. A malaria parasite of rodents, P. …
berghei genomic DNA (gDNA) can be propagated efficiently in E. coli as large genomic inserts …
berghei genomic DNA (gDNA) can be propagated efficiently in E. coli as large genomic inserts …
Reverse genetics screen identifies six proteins important for malaria development in the mosquito
A Ecker, ESC Bushell, R Tewari… - Molecular …, 2008 - Wiley Online Library
Transmission from the vertebrate host to the mosquito vector represents a major population
bottleneck in the malaria life cycle that can successfully be targeted by intervention strategies…
bottleneck in the malaria life cycle that can successfully be targeted by intervention strategies…
CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact
…, MS Paoletta, T Sanderson, ESC Bushell - Biochemical Society …, 2022 - portlandpress.com
… Nonetheless, >2 kb Plasmodium DNA fragments are difficult to clone and stably maintain in
E. coli, and scaling up restriction-ligation cloning is impractical. The challenges of generating …
E. coli, and scaling up restriction-ligation cloning is impractical. The challenges of generating …
PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites
… berghei genomic DNA unstable in E. coli. The latter problem can be overcome in part by …
berghei genes in their entirety to be maintained in E. coli for the first time (3). We have recently …
berghei genes in their entirety to be maintained in E. coli for the first time (3). We have recently …
[PDF][PDF] Genome-scale identification of essential metabolic processes for targeting the Plasmodium liver stage
RR Stanway, E Bushell, A Chiappino-Pepe, M Roques… - Cell, 2019 - cell.com
Plasmodium gene functions in mosquito and liver stages remain poorly characterized due
to limitations in the throughput of phenotyping at these stages. To fill this gap, we followed …
to limitations in the throughput of phenotyping at these stages. To fill this gap, we followed …
Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals
… There are two additional novel gene families in the avian malaria genomes fam-e and
fam-i. Fam-e is present in both avian malaria species and is a two-exon gene with an average …
fam-i. Fam-e is present in both avian malaria species and is a two-exon gene with an average …
Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi …
Fertilization is a crucial yet poorly characterized event in eukaryotes. Our previous discovery
that the broadly conserved protein HAP2 (GCS1) functioned in gamete membrane fusion in …
that the broadly conserved protein HAP2 (GCS1) functioned in gamete membrane fusion in …
Global analysis of apicomplexan protein S‐acyl transferases reveals an enzyme essential for invasion
K Frénal, CL Tay, C Mueller, ES Bushell, Y Jia… - Traffic, 2013 - Wiley Online Library
The advent of techniques to study palmitoylation on a whole proteome scale has revealed
that it is an important reversible modification that plays a role in regulating multiple biological …
that it is an important reversible modification that plays a role in regulating multiple biological …