The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

A debate has recently arisen over the use of racial classification in medicine and biomedical
research. In particular, with the completion of a rough draft of the human genome, some …

… (a) We assume that the probability (P) of trait D depends only on E, so that the risk of D … of
D within strata defined by G and E. First, we assume G and E are frequency-independent within …

Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes.
Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role …

Medical genomics has focused almost entirely on those of European descent. Other ethnic
groups must be studied to ensure that more people benefit, say Carlos D. Bustamante …

… clearance (at least in the individuals with only reference alleles) contributes significantly to
the total clearance of metformin, the bioavailability actually could not be calculated from the f e…

… Burchard … Wu AH, White MJ, Oh SS, Burchard E. The Hawaii clopidogrel lawsuit: the
possible effect on clinical laboratory testing. Per Med. … Burchard EG, Oh SS, Foreman MG …