It has become increasingly clear that the simple neurodevelopmental model fails to explain
many aspects of schizophrenia including the timing of the onset, and the nature of the …

… E. Bramon holds a MRC New Investigator Award and was further supported by a MRC
Centenary Award, the National Institute of Health Research UK (post-doctoral fellowship), the …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …

Reduced fecundity, associated with severe mental disorders 1 , places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …

Current psychiatric nosology, strongly influenced by Kraepelin’s dichotomy [1,2], classifies
schizophrenia and bipolar disorder as separate diagnostic categories. However, growing …

… It has become standard practice in GWAS to refer to the odds ratio associated with a
particular allele or haplotype, which we estimate as e β , where β is the maximum likelihood …

Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting
the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. …

Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have
also been reported in two families with schizophrenia. We examined NRXN1, and the …

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …