The joint contribution of pre-existing and de novo genetic variation to clonal adaptation is
poorly understood but essential to designing successful antimicrobial or cancer therapies. To …

Increasing evidence supports the involvement of autophagy in the etiopathology of autoimmune
diseases. Despite the identification of autophagy-related protein (Atg)-5 as one of the …

Genetic variation in the interferon regulatory factor 5 (IRF5) gene affects systemic lupus
erythematosus (SLE) susceptibility. However, association is complex and incompletely defined. …

A single amino acid residue change in the exonuclease domain of human DNA polymerase
ϵ, P286R, is associated with the development of colorectal cancers, and has been shown to …

During DNA replication, the newly created sister chromatids are held together until their
separation at anaphase. The cohesin complex is in charge of creating and maintaining sister …

Introduction Systemic Lupus Erythematosus (SLE) shows a spectrum of clinical manifestations
that complicate its diagnosis, treatment and research. This variability is likely related with …

Background Differences in type 2 diabetes risk have been reported for several sociodemographic
determinants including sex/gender or socioeconomic status. From an intersectional …

Introduction We aimed to replicate a recent study which showed higher genetic risk load at
15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was …

… Estrella Alonso Pérez received the mathematics degree from the Universidad Autnoma de
Madrid in 1998, and the Ph.D. degree from the Universidad Complutense de Madrid, Spain, in …

Systemic Lupus Erythematosus (SLE) is an autoimmune disease with a very varied spectrum
of clinical manifestations that could be partly determined by genetic factors. We aimed to …