A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

…, TT Valle, L Kinnunen, GR Abecasis, EW Pugh… - science, 2007 - science.org
Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has
been a formidable challenge. Adopting a genome-wide association strategy, we genotyped …

A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4

…, K Christensen, M Melbye, KF Doheny, EW Pugh… - Nature …, 2010 - nature.com
Case-parent trios were used in a genome-wide association study of cleft lip with and without
cleft palate. SNPs near two genes not previously associated with cleft lip with and without …

Detectable clonal mosaicism from birth to old age and its relationship to cancer

…, CP McHugh, H Ling, KN Hetrick, EW Pugh… - Nature …, 2012 - nature.com
We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …

[BOOK][B] Building IBM: shaping an industry and its technology

EW Pugh - 2009 - books.google.com
… In reviewing the first of these books, the Boston Globe said, “Pugh's book is to good business
magazine journalism as Jane Austen is to New Yorker fiction." That accolade seems even …

Genetic variants near TIMP3 and high-density lipoprotein–associated loci influence susceptibility to age-related macular degeneration

…, M Sanchez-Salorio, EW Pugh… - Proceedings of the …, 2010 - National Acad Sciences
We executed a genome-wide association scan for age-related macular degeneration (AMD)
in 2,157 cases and 1,150 controls. Our results validate AMD susceptibility loci near CFH (P …

[PDF][PDF] A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

…, Z Wang, L Burdette, KF Doheny, EW Pugh… - The american journal of …, 2009 - cell.com
Three genetic loci for lung cancer risk have been identified by genome-wide association
studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well …

Quality control and quality assurance in genotypic data for genome‐wide association studies

CC Laurie, KF Doheny, DB Mirel, EW Pugh… - Genetic …, 2010 - Wiley Online Library
Genome‐wide scans of nucleotide variation in human subjects are providing an increasing
number of replicated associations with complex disease traits. Most of the variants detected …

Genomewide association study for susceptibility genes contributing to familial Parkinson disease

…, JC Latourelle, AL DeStefano, C Halter, EW Pugh… - Human genetics, 2009 - Springer
Five genes have been identified that contribute to Mendelian forms of Parkinson disease (PD);
however, mutations have been found in fewer than 5% of patients, suggesting that …

[BOOK][B] IBM's 360 and Early 370 Systems

EW Pugh, LR Johnson, JH Palmer - 1991 - books.google.com
No new product offering has had greater impact on the computer industry than the IBM
System/360. IBM's 360 and Early 370 Systems describes the creation of this remarkable system …

Common variants in the GDF5-UQCC region are associated with variation in human height

…, G Albai, L Crisponi, S Naitza, KF Doheny, EW Pugh… - Nature …, 2008 - nature.com
Identifying genetic variants that influence human height will advance our understanding of
skeletal growth and development. Several rare genetic variants have been convincingly and …