Epistatic interactions between mutations can make evolutionary trajectories contingent on the
chance occurrence of initial mutations. We used experimental evolution in Saccharomyces …

Young’s classic analysis of the equilibrium of a three-phase contact line ignores the out-of-plane
component of the liquid-vapor surface tension. While it is expected that this unresolved …

Natural environments are never truly constant, but the evolutionary implications of temporally
varying selection pressures remain poorly understood. Here we investigate how the fate of …

The vast majority of mutations are deleterious and are eliminated by purifying selection. Yet
in finite asexual populations, purifying selection cannot completely prevent the accumulation …

Laboratory experimental evolution provides a window into the details of the evolutionary
process. To investigate the consequences of long-term adaptation, we evolved 205 …

Colloidal coatings, such as paint, are all around us. However, we know little about the mechanics
of the film-forming process because the composition and properties of drying coatings …

10.7554/eLife.27167.001 Evolution can favor organisms that are more adaptable, provided
that genetic variation in adaptability exists. Here, we quantify this variation among 230 …

Microbial evolution experiments enable us to watch adaptation in real time, and to quantify
the repeatability and predictability of evolution by comparing identical replicate populations. …

Mutations that a population accumulates during evolution in one ‘home’ environment may
cause fitness gains or losses in other environments. Such pleiotropic fitness effects determine …

T cells in vivo migrate primarily via undirected random walks, but it remains unresolved how
these random walks generate an efficient search. Here, we use light sheet microscopy of T …