[PDF][PDF] Targeting Mycobacterium tuberculosis sensitivity to thiol stress at acidic pH kills the bacterium and potentiates antibiotics
…, H Zheng, CJ Colvin, RJ Fillinger, ER Haiderer… - Cell chemical …, 2017 - cell.com
Mycobacterium tuberculosis (Mtb) must sense and adapt to immune pressures such as acidic
pH during pathogenesis. The goal of this study was to isolate compounds that inhibit acidic …
pH during pathogenesis. The goal of this study was to isolate compounds that inhibit acidic …
Identification of new MmpL3 inhibitors by untargeted and targeted mutant screens defines MmpL3 domains with differential resistance
JT Williams, ER Haiderer, GB Coulson… - Antimicrobial agents …, 2019 - Am Soc Microbiol
The Mycobacterium tuberculosis mycolate flippase MmpL3 has been the proposed target for
multiple inhibitors with diverse chemical scaffolds. This diversity in chemical scaffolds has …
multiple inhibitors with diverse chemical scaffolds. This diversity in chemical scaffolds has …
HC2091 kills Mycobacterium tuberculosis by targeting the MmpL3 mycolic acid transporter
…, JT Williams, GB Coulson, ER Haiderer… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis , is a deadly
disease that requires a long course of treatment. The emergence of drug-resistant strains …
disease that requires a long course of treatment. The emergence of drug-resistant strains …
Discovery and characterization of antimycobacterial nitro-containing compounds with distinct mechanisms of action and in vivo efficacy
IE Eke, JT Williams, ER Haiderer… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Nitro-containing compounds have emerged as important agents in the control of tuberculosis
(TB). From a whole-cell high-throughput screen for Mycobacterium tuberculosis (Mtb) …
(TB). From a whole-cell high-throughput screen for Mycobacterium tuberculosis (Mtb) …
The Mycobacterium tuberculosis MmpL3 inhibitor MSU-43085 is active in a mouse model of infection
JT Williams, M Giletto, ER Haiderer, B Aleiwi… - Microbiology …, 2024 - Am Soc Microbiol
Addressing drug resistance in Mycobacterium tuberculosis (Mtb) requires the development
of new drugs with new targets. We previously identified 13 MmpL3 inhibitors from a screen of …
of new drugs with new targets. We previously identified 13 MmpL3 inhibitors from a screen of …
Acidic pH-dependent depletion of Mycobacterium tuberculosis thiol pools potentiates antibiotics and oxidizing agents
…, CJ Colvin, RJ Fillinger, H Zheng, ER Haiderer… - bioRxiv, 2016 - biorxiv.org
Mycobacterium tuberculosis (Mtb) must sense and adapt to immune pressures such as acidic
pH and reactive oxygen species (ROS) during pathogenesis. The goal of this study was to …
pH and reactive oxygen species (ROS) during pathogenesis. The goal of this study was to …
HC2091 kills Mycobacterium tuberculosis by targeting the MmpL3 mycolic acid transporter.
…, JT Williams, GB Coulson, ER Haiderer… - 2018 - cabidigitallibrary.org
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, is a deadly
disease that requires a long course of treatment. The emergence of drug-resistant strains …
disease that requires a long course of treatment. The emergence of drug-resistant strains …
Closed visceral injuries of abdomen and thorax
JH Kennedy, O Haiderer, RW Hopkins - Jama, 1967 - jamanetwork.com
… The venous catheter, passed via a median basilic phlebotomy as part of the initial
resuscitation in the emergency room, may be used for serial estimations of the central …
resuscitation in the emergency room, may be used for serial estimations of the central …
A Selected Bibliography from Foreign Journals: January, February and March 1955
F Haiderer, M Alisky, LJ Martin… - Journalism …, 1955 - journals.sagepub.com
This quarter has seen the celebration of several newspaper anniversaries. Among them are
the Neue Zürcher Zeitung (175 years), El Comercio of Ecuador (50 years), the Daily Herald (…
the Neue Zürcher Zeitung (175 years), El Comercio of Ecuador (50 years), the Daily Herald (…
[CITATION][C] Targeting Mycobacterium tuberculosis sensitivity to thiol stress at acidic ph kills the bacterium and potentiates antibiotics. Cell Chem Biol. 2017; 24 (8): 993 …
…, H Zheng, CJ Colvin, RJ Fillinger, ER Haiderer