User profiles for E. M. Marcotte

Edward Marcotte

Professor of Molecular Biosciences, University of Texas at Austin
Verified email at utexas.edu
Cited by 44786

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

C Vogel, EM Marcotte - Nature reviews genetics, 2012 - nature.com
Recent advances in next-generation DNA sequencing and proteomics provide an unprecedented
ability to survey mRNA and protein abundances. Such proteome-wide surveys are …

Global signatures of protein and mRNA expression levels

R de Sousa Abreu, LO Penalva, EM Marcotte… - Molecular …, 2009 - pubs.rsc.org
Cellular states are determined by differential expression of the cell’s proteins. The relationship
between protein and mRNA expression levels informs about the combined outcomes of …

Protein function in the post-genomic era

D Eisenberg, EM Marcotte, I Xenarios, TO Yeates - Nature, 2000 - nature.com
Faced with the avalanche of genomic sequences and data on messenger RNA expression,
biological scientists are confronting a frightening prospect: piles of information but only flakes …

Assigning protein functions by comparative genome analysis: protein phylogenetic profiles

M Pellegrini, EM Marcotte… - Proceedings of the …, 1999 - National Acad Sciences
Determining protein functions from genomic sequences is a central goal of bioinformatics.
We present a method based on the assumption that proteins that function together in a …

Detecting protein function and protein-protein interactions from genome sequences

EM Marcotte, M Pellegrini, HL Ng, DW Rice, TO Yeates… - Science, 1999 - science.org
Marcotte, Matteo Pellegrini … EM was supported by a DOE Hollaender fellowship. We
thank MK Baron for her work with the Database of Interacting Proteins. … Marcotte et al. …

Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation

P Lu, C Vogel, R Wang, X Yao, EM Marcotte - Nature biotechnology, 2007 - nature.com
We report a method for large-scale absolute protein expression measurements (APEX) and
apply it to estimate the relative contributions of transcriptional- and translational-level gene …

DIP: the database of interacting proteins

…, L Salwinski, MK Baron, EM Marcotte… - Nucleic acids …, 2000 - academic.oup.com
The Database of Interacting Proteins (DIP; http://dip.doe-mbi.ucla.edu ) is a database that
documents experimentally determined protein–protein interactions. This database is intended …

A combined algorithm for genome-wide prediction of protein function

EM Marcotte, M Pellegrini, MJ Thompson, TO Yeates… - Nature, 1999 - nature.com
The availability of over 20 fully sequenced genomes has driven the development of new
methods to find protein function and interactions. Here we group proteins by correlated …

[HTML][HTML] A census of human soluble protein complexes

…, SJ Wodak, ERM Tillier, A Paccanaro, EM Marcotte… - Cell, 2012 - cell.com
Cellular processes often depend on stable physical associations between proteins. Despite
recent progress, knowledge of the composition of human protein complexes remains limited. …

[HTML][HTML] Genome evolution in the allotetraploid frog Xenopus laevis

…, L DuPasquier, PD Vize, AM Zorn, M Ito, EM Marcotte… - Nature, 2016 - nature.com
To explore the origins and consequences of tetraploidy in the African clawed frog, we sequenced
the Xenopus laevis genome and compared it to the related diploid X. tropicalis genome…