It has been appreciated for some time that the sexes can differ in their sensitivity to pain and
its inhibition. Both the human and rodent literatures remain quite contentious, with many …

Laboratory conditions in biobehavioral experiments are commonly assumed to be ‘controlled’,
having little impact on the outcome. However, recent studies have illustrated that the …

Complex traits and disease comorbidity in humans and in model organisms are the result of
naturally occurring polymorphisms that interact with each other and with the environment. To …

Patterns of gene expression in the central nervous system are highly variable and heritable.
This genetic variation among normal individuals leads to considerable structural, functional …

Sex specificity of neural mechanisms modulating nociceptive information has been demonstrated
in rodents, and these qualitative sex differences appear to be relevant to analgesia …

The JAX Diversity Outbred population is a new mouse resource derived from partially
inbred Collaborative Cross strains and maintained by randomized outcrossing. As such, it …

… In an accompanying paper, Chesler and colleagues dissected variation in expression profiles
in forebrain of the same strains of mice 17 . One of the advantages of this approach is that …

The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being
developed as a resource for mammalian systems genetics. Here we describe an experiment that …

Large projects are often carried out by multiple undergraduate and graduate students, postdocs,
technicians and other transient personnel. Furthermore, research, particularly on mutant …

Inbred mice are preferred over outbred mice because it is assumed that they display less trait
variability. We compared coefficients of variation and did not find evidence of greater trait …