User profiles for E. E. Schadt
 | Eric SchadtProfessor of Genetics and Genomic Sciences, Mount Sinai School of Medicine Verified email at mssm.edu Cited by 199319 |
A window into third-generation sequencing
EE Schadt, S Turner, A Kasarskis - Human molecular genetics, 2010 - academic.oup.com
First- and second-generation sequencing technologies have led the way in revolutionizing
the field of genomics and beyond, motivating an astonishing number of scientific advances, …
the field of genomics and beyond, motivating an astonishing number of scientific advances, …
Molecular networks as sensors and drivers of common human diseases
EE Schadt - Nature, 2009 - nature.com
… Schadt, EE et al. Mapping the genetic architecture of gene expression in human liver. PLoS
… Schadt, EE et al. An integrative genomics approach to infer causal associations between …
… Schadt, EE et al. An integrative genomics approach to infer causal associations between …
Computational solutions to large-scale data management and analysis
Today we can generate hundreds of gigabases of DNA and RNA sequencing data in a week
for less than US$5,000. The astonishing rate of data generation by these low-cost, high-…
for less than US$5,000. The astonishing rate of data generation by these low-cost, high-…
[HTML][HTML] An integrated map of structural variation in 2,504 human genomes
…, M Pendleton, A Quitadamo, B Raeder, EE Schadt… - Nature, 2015 - nature.com
Structural variants are implicated in numerous diseases and make up the majority of varying
nucleotides among human genomes. Here we describe an integrated set of eight structural …
nucleotides among human genomes. Here we describe an integrated set of eight structural …
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
[HTML][HTML] Bayesian test for colocalisation between pairs of genetic association studies using summary statistics
Genetic association studies, in particular the genome-wide association study (GWAS)
design, have provided a wealth of novel insights into the aetiology of a wide range of human …
design, have provided a wealth of novel insights into the aetiology of a wide range of human …
Genetics of gene expression surveyed in maize, mouse and man
EE Schadt, SA Monks, TA Drake, AJ Lusis, N Che… - Nature, 2003 - nature.com
Treating messenger RNA transcript abundances as quantitative traits and mapping gene
expression quantitative trait loci for these traits has been pursued in gene-specific ways. …
expression quantitative trait loci for these traits has been pursued in gene-specific ways. …
[PDF][PDF] Geroscience: linking aging to chronic disease
Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches.
Given that the elderly population is dramatically increasing and that aging is the greatest risk …
Given that the elderly population is dramatically increasing and that aging is the greatest risk …
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays
Alternative pre–messenger RNA (pre-mRNA) splicing plays important roles in development,
physiology, and disease, and more than half of human genes are alternatively spliced. To …
physiology, and disease, and more than half of human genes are alternatively spliced. To …
[HTML][HTML] Origins of the E. coli Strain Causing an Outbreak of Hemolytic–Uremic Syndrome in Germany
Background A large outbreak of diarrhea and the hemolytic–uremic syndrome caused by an
unusual serotype of Shiga-toxin–producing Escherichia coli (O104:H4) began in Germany …
unusual serotype of Shiga-toxin–producing Escherichia coli (O104:H4) began in Germany …