We study the structure of social networks of students by examining the graphs of Facebook “friendships”
at five US universities at a single point in time. We investigate the community …

A key aspect of bacterial survival is the ability to evolve while migrating across spatially varying
environmental challenges. Laboratory experiments, however, often study evolution in well…

Modern experimental technologies can assay large numbers of biological sequences, but
engineered protein libraries rarely exceed the sequence diversity of natural protein families. …

Classical theory shows that large communities are destabilized by random interactions
among species pairs, creating an upper bound on ecosystem diversity. However, species …

A major challenge in theoretical ecology is understanding how natural microbial communities
support species diversity 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , and in particular how antibiotic-producing…

Adeno-associated virus (AAV) capsids can deliver transformative gene therapies, but our
understanding of AAV biology remains incomplete. We generated the complete first-order …

Construction and characterization of large genetic variant libraries is essential for understanding
genome function, but remains challenging. Here, we introduce a Cas9-based approach …

Efficient design of biological sequences will have a great impact across many industrial and
healthcare domains. However, discovering improved sequences requires solving a difficult …

Synonymous codon choices at the beginning of genes optimize 5′ RNA structures for
enhanced translation initiation, but less is known about mechanisms that drive codon …

Machine learning methods are increasingly employed to address challenges faced by biologists.
One area that will greatly benefit from this cross-pollination is the problem of biological …