… tWe call this region 'middle' instead of 'spacer' as it was previously designated, because
recent evidence indicates that this region is important for function (EC Schirmer and S. Lindquist, …

Lamin-associated polypeptides (LAPs) comprise inner nuclear membrane proteins tightly
associated with the peripheral lamin scaffold as well as proteins forming stable complexes with …

The marriage of proteomics with cell biology has produced extensive inventories of the
proteins that inhabit several subcellular organelles. Recent proteomic analysis has identified …

To comprehensively identify integral membrane proteins of the nuclear envelope (NE), we
prepared separately NEs and organelles known to cofractionate with them from liver. Proteins …

The [PSI + ] factor of S. cerevisiae represents a new form of inheritance: cytosolic transmission
of an altered phenotype is apparently based upon inheritance of an altered protein …

A new human herpesvirus has been isolated from CD4+ T cells purified from peripheral
blood mononuclear cells of a healthy individual (RK), following incubation of the cells under …

One hypothesis to explain how mutations in the same nuclear envelope proteins yield
pathologies focused in distinct tissues is that as yet unidentified tissue-specific partners mediate …

Human herpesvirus 6 (HHV-6) causes exanthem subitum (ES, roseola infantum), a childhood
disease characterized by high fever and skin rash. We have analyzed restriction enzyme …

Whether gene repositioning to the nuclear periphery during differentiation adds another
layer of regulation to gene expression remains controversial. Here, we resolve this by …

While analyzing the DNA methylome of multiple myeloma (MM), a plasma cell neoplasm, by
whole-genome bisulfite sequencing and high-density arrays, we observed a highly …