Clozapine has superior and unique effects as an antipsychotic agent, but the mediators of
these effects are not known. We studied behavioral and developmental effects of clozapine in …

The cytoskeleton not only provides structure, it is an active component of cell function, and
in several neurodegenerative disorders, there is evidence of cytoskeletal collapse. …

Many important drugs approved to treat common human diseases were discovered by
serendipity, without a firm understanding of their modes of action. As a result, the side effects and …

Mycobacterium abscessus is a ubiquitous, saprophytic organism with low pathogenic potential.
The authors describe the previously unreported clinical features of meningitis and native …

An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal mutation
associated with amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration (…

… We thank Buttner lab members for advice and discussions, and Theresa Stiernagle at the
C. elegans Genetic Center and the National BioResource Project (Tokyo, Japan) for strains …

Clozapine is an antipsychotic medication with superior efficacy in treatment refractory
schizophrenia. The molecular basis of clozapine's therapeutic profile is not well understood. We …

How mutations in human genes cause disease remains unclear in most cases. If we can
understand the molecular mechanisms through which specific genes cause or increase the risk …

… This work is dedicated to the memory of Dr Edgar (Ned) A Buttner, who passed away on
15 October 2015, for his inspiring enthusiasm, warm collegiality, and excellence in science. …

Caenorhabditis elegans is a simple genetic organism amenable to large-scale forward and
reverse genetic screens and chemical genetic screens. The C. elegans genome includes …