Fungal effector Ecp6 outcompetes host immune receptor for chitin binding through intrachain LysM dimerization

…, A Kombrink, G Hansen, DJ Valkenburg… - elife, 2013 - elifesciences.org
10.7554/eLife.00790.001 While host immune receptors detect pathogen-associated molecular
patterns to activate immunity, pathogens attempt to deregulate host immunity through …

Verticillium dahliae LysM effectors differentially contribute to virulence on plant hosts

…, R De Jonge, DJ Valkenburg… - Molecular plant …, 2017 - Wiley Online Library
Chitin‐binding lysin motif (LysM) effectors contribute to the virulence of various plant‐pathogenic
fungi that are causal agents of foliar diseases. Here, we report the LysM effectors of the …

[HTML][HTML] A secreted LysM effector protects fungal hyphae through chitin-dependent homodimer polymerization

…, H Tian, L Rodriguez-Moreno, DJ Valkenburg… - PLoS …, 2020 - journals.plos.org
Plants trigger immune responses upon recognition of fungal cell wall chitin, followed by the
release of various antimicrobials, including chitinase enzymes that hydrolyze chitin. In turn, …

Doping control, providing whereabouts and the importance of privacy for elite athletes

D Valkenburg, O De Hon, I Van Hilvoorde - International journal of drug …, 2014 - Elsevier
Background To improve anti-doping efforts in sports, the World Anti-Doping Agency (WADA)
introduced the World Anti-Doping Program, in which (among others) regulations for …

Transfer of tomato immune receptor Ve1 confers Ave1‐dependent Verticillium resistance in tobacco and cotton

Y Song, L Liu, Y Wang, DJ Valkenburg… - Plant biotechnology …, 2018 - Wiley Online Library
Verticillium wilts caused by soilborne fungal species of the Verticillium genus are economically
important plant diseases that affect a wide range of host plants and are notoriously …

[HTML][HTML] Foveal sparing in central retinal dystrophies

NM Bax, D Valkenburg, S Lambertus… - … & visual science, 2019 - tvst.arvojournals.org
… Fundus autofluorescence images of the right (A–C) and left (D–F) eye of a Stargardt patient
with asymmetrical foveal sparing. Multifocal areas of RPE atrophy (A) develop and coalesce …

[HTML][HTML] Late-onset Stargardt disease due to mild, deep-intronic ABCA4 alleles

EH Runhart, D Valkenburg, SS Cornelis… - … & visual science, 2019 - iovs.arvojournals.org
Purpose: To investigate the role of two deep-intronic ABCA4 variants, that showed a mild
splice defect in vitro and can occur on the same allele as the low penetrant c. 5603A> T, in …

[HTML][HTML] The Brassicaceae-Specific EWR1 Gene Provides Resistance to Vascular Wilt Pathogens

KA Yadeta, DJ Valkenburg, M Hanemian, Y Marco… - PLoS …, 2014 - journals.plos.org
Soil-borne vascular wilt diseases caused by Verticillium spp. are among the most destructive
diseases worldwide in a wide range of plant species. The most effective means of …

[HTML][HTML] Clinical characterization of 66 patients with congenital retinal disease due to the deep-intronic c. 2991+ 1655A> G mutation in CEP290

D Valkenburg, C Van Cauwenbergh… - … & visual science, 2018 - iovs.arvojournals.org
Purpose: To describe the phenotypic spectrum of retinal disease caused by the c. 2991+
1655A> G mutation in CEP290 and to compare disease severity between homozygous and …

Highly variable disease courses in siblings with Stargardt disease

D Valkenburg, EH Runhart, NM Bax, B Liefers… - Ophthalmology, 2019 - Elsevier
… A 3 –D 3 , Foveal OCT scan lines corresponding to the FAF images revealing extensive
outer retinal degeneration corresponding to hypoautofluorescence on FAF. A foveal-sparing …