User profiles for D. Thybert
David ThybertGSK Verified email at gsk.com Cited by 4314 |
Ensembl 2022
Ensembl ( https://www.ensembl.org ) is unique in its flexible infrastructure for access to genomic
data and annotation. It has been designed to efficiently deliver annotation at scale for all …
data and annotation. It has been designed to efficiently deliver annotation at scale for all …
Ensembl 2021
The Ensembl project ( https://www.ensembl.org ) annotates genomes and disseminates
genomic data for vertebrate species. We create detailed and comprehensive annotation of gene …
genomic data for vertebrate species. We create detailed and comprehensive annotation of gene …
Ensembl 2023
Ensembl ( https://www.ensembl.org ) has produced high-quality genomic resources for
vertebrates and model organisms for more than twenty years. During that time, our resources, …
vertebrates and model organisms for more than twenty years. During that time, our resources, …
[HTML][HTML] Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci
…, C Steward, M Thomas, G Threadgold, D Thybert… - Nature …, 2018 - nature.com
We report full-length draft de novo genome assemblies for 16 widely used inbred mouse strains
and find extensive strain-specific haplotype variation. We identify and characterize 2,567 …
and find extensive strain-specific haplotype variation. We identify and characterize 2,567 …
[HTML][HTML] Cooperativity and rapid evolution of cobound transcription factors in closely related mammals
To mechanistically characterize the microevolutionary processes active in altering
transcription factor (TF) binding among closely related mammals, we compared the genome-wide …
transcription factor (TF) binding among closely related mammals, we compared the genome-wide …
Extensive compensatory cis-trans regulation in the evolution of mouse gene expression
A Goncalves, S Leigh-Brown, D Thybert… - Genome …, 2012 - genome.cshlp.org
Gene expression levels are thought to diverge primarily via regulatory mutations in trans
within species, and in cis between species. To test this hypothesis in mammals we used RNA-…
within species, and in cis between species. To test this hypothesis in mammals we used RNA-…
[PDF][PDF] Random monoallelic gene expression increases upon embryonic stem cell differentiation
… (C) Examples of class A, B, and C transcripts showing the behavior of individual clones (C)
with respect to the d score and p value. (D) Summary table of the number of genes and …
with respect to the d score and p value. (D) Summary table of the number of genes and …
The quest for orthologs orthology benchmark service in 2022
The Orthology Benchmark Service ( https://orthology.benchmarkservice.org ) is the gold
standard for orthology inference evaluation, supported and maintained by the Quest for …
standard for orthology inference evaluation, supported and maintained by the Quest for …
Chromosome assembly of large and complex genomes using multiple references
… (D) Missing adjacencies are recovered based on the graph structure and phylogenetic
tree. Since T is closer to R 1 , the algorithm prefers the pair of breakpoints (b t , c h ), (…
tree. Since T is closer to R 1 , the algorithm prefers the pair of breakpoints (b t , c h ), (…
Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes
… (D) The rate of synteny breaks between sequential internal branch points of the Muridae
and Hominidae clades. Muridae have undergone a punctuate increase in the rate of syntenic …
and Hominidae clades. Muridae have undergone a punctuate increase in the rate of syntenic …