User profiles for D. Thybert

David Thybert

GSK
Verified email at gsk.com
Cited by 4314

Ensembl 2022

…, E Perry, M Ruffier, J Tate, D Thybert… - Nucleic acids …, 2022 - academic.oup.com
Ensembl ( https://www.ensembl.org ) is unique in its flexible infrastructure for access to genomic
data and annotation. It has been designed to efficiently deliver annotation at scale for all …

Ensembl 2021

…, E Perry, M Ruffier, J Tate, D Thybert… - Nucleic acids …, 2021 - academic.oup.com
The Ensembl project ( https://www.ensembl.org ) annotates genomes and disseminates
genomic data for vertebrate species. We create detailed and comprehensive annotation of gene …

Ensembl 2023

…, B Moore, JM Mudge, J Tate, D Thybert… - Nucleic acids …, 2023 - academic.oup.com
Ensembl ( https://www.ensembl.org ) has produced high-quality genomic resources for
vertebrates and model organisms for more than twenty years. During that time, our resources, …

[HTML][HTML] Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci

…, C Steward, M Thomas, G Threadgold, D Thybert… - Nature …, 2018 - nature.com
We report full-length draft de novo genome assemblies for 16 widely used inbred mouse strains
and find extensive strain-specific haplotype variation. We identify and characterize 2,567 …

[HTML][HTML] Cooperativity and rapid evolution of cobound transcription factors in closely related mammals

K Stefflova, D Thybert, MD Wilson, I Streeter, J Aleksic… - Cell, 2013 - cell.com
To mechanistically characterize the microevolutionary processes active in altering
transcription factor (TF) binding among closely related mammals, we compared the genome-wide …

Extensive compensatory cis-trans regulation in the evolution of mouse gene expression

A Goncalves, S Leigh-Brown, D Thybert… - Genome …, 2012 - genome.cshlp.org
Gene expression levels are thought to diverge primarily via regulatory mutations in trans
within species, and in cis between species. To test this hypothesis in mammals we used RNA-…

[PDF][PDF] Random monoallelic gene expression increases upon embryonic stem cell differentiation

MA Eckersley-Maslin, D Thybert, JH Bergmann… - Developmental cell, 2014 - cell.com
… (C) Examples of class A, B, and C transcripts showing the behavior of individual clones (C)
with respect to the d score and p value. (D) Summary table of the number of genes and …

The quest for orthologs orthology benchmark service in 2022

…, DS Roos, T Gabaldón, D Thybert… - Nucleic Acids …, 2022 - academic.oup.com
The Orthology Benchmark Service ( https://orthology.benchmarkservice.org ) is the gold
standard for orthology inference evaluation, supported and maintained by the Quest for …

Chromosome assembly of large and complex genomes using multiple references

…, D Odom, P Flicek, TM Keane, D Thybert… - Genome …, 2018 - genome.cshlp.org
… (D) Missing adjacencies are recovered based on the graph structure and phylogenetic
tree. Since T is closer to R 1 , the algorithm prefers the pair of breakpoints (b t , c h ), (…

Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes

D Thybert, M Roller, FCP Navarro, I Fiddes… - Genome …, 2018 - genome.cshlp.org
… (D) The rate of synteny breaks between sequential internal branch points of the Muridae
and Hominidae clades. Muridae have undergone a punctuate increase in the rate of syntenic …