User profiles for D. Speed

Doug Speed

- Verified email at qgg.au.dk - Cited by 10643

David Fast

- Verified email at gdit.com - Cited by 2057

Relatedness in the post-genomic era: is it still useful?

D Speed, DJ Balding - Nature Reviews Genetics, 2015 - nature.com
Relatedness is a fundamental concept in genetics but is surprisingly hard to define in a
rigorous yet useful way. Traditional relatedness coefficients specify expected genome sharing …

Considerations of environmentally relevant test conditions for improved evaluation of ecological hazards of engineered nanomaterials

…, M Scheringer, M Sharma, DE Speed… - … science & technology, 2016 - ACS Publications
Engineered nanomaterials (ENMs) are increasingly entering the environment with uncertain
consequences including potential ecological effects. Various research communities view …

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

…, G Turashvili, OM Rueda, MJ Dunning, D Speed… - Nature, 2012 - nature.com
The elucidation of breast cancer subgroups and their molecular drivers requires integrated
views of the genome and transcriptome from representative numbers of patients. We present …

Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illnesses

GA Bohach, DJ Fast, RD Nelson… - Critical reviews in …, 1990 - Taylor & Francis
Toxic-shock syndrome (TSS) is an acute onset, multiorgan illness which resembles severe
scarlet fever. The illness is caused by Staphylococcus aureus strains that express TSS toxin-1 …

[PDF][PDF] Improved heritability estimation from genome-wide SNPs

D Speed, G Hemani, MR Johnson… - The American Journal of …, 2012 - cell.com
… Using the weights defined by Equation 7 instead gave results intermediate between those
based on A and A* (results not shown, but follow from Figure S1D). Even if causal variants are …

[HTML][HTML] Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast

DC Jeffares, C Jolly, M Hoti, D Speed, L Shaw… - Nature …, 2017 - nature.com
… of chromosomes (0.1 kb–5,374 kb, see d). Horizontal dotted lines show the size of chromosome
… (d) Locations of SVs on the three chromosomes compared with other genomic features. …

Reevaluation of SNP heritability in complex human traits

D Speed, N Cai, Ucleb Consortium, MR Johnson… - Nature …, 2017 - nature.com
… By way of demonstration, Supplementary Table 10 shows that model fit is improved by
assuming where D j is the distance (in kb) between SNP j and the nearest exon (under this model, …

[HTML][HTML] Graph pangenome captures missing heritability and empowers tomato breeding

…, L Mueller, Z Fei, T Städler, S Xu, Z Zhang, D Speed… - Nature, 2022 - nature.com
d, Comparison of genomic selection accuracies using SNPs and SVs as markers. The colour
scale indicates the estimated heritability contributed by SNPs. e, Comparison of genomic …

Inactivation of faecal indicator micro-organisms in waste stabilisation ponds: interactions of environmental factors with sunlight

RJ Davies-Colley, AM Donnison, DJ Speed, CM Ross… - Water research, 1999 - Elsevier
Sunlight exposure is considered to be the most important cause of “natural” disinfection in
waste stabilisation ponds (WSPs). We examined the influence of dissolved oxygen (DO), pH, …

MultiBLUP: improved SNP-based prediction for complex traits

D Speed, DJ Balding - Genome research, 2014 - genome.cshlp.org
… ], and construct the diagonal matrix D with diagonal elements consisting of Graphic repeated
… and D is diagonal, the only inversion required is of the lower-dimensioned matrix (D −1 + Z…