Relatedness in the post-genomic era: is it still useful?
D Speed, DJ Balding - Nature Reviews Genetics, 2015 - nature.com
Relatedness is a fundamental concept in genetics but is surprisingly hard to define in a
rigorous yet useful way. Traditional relatedness coefficients specify expected genome sharing …
rigorous yet useful way. Traditional relatedness coefficients specify expected genome sharing …
Considerations of environmentally relevant test conditions for improved evaluation of ecological hazards of engineered nanomaterials
…, M Scheringer, M Sharma, DE Speed… - … science & technology, 2016 - ACS Publications
Engineered nanomaterials (ENMs) are increasingly entering the environment with uncertain
consequences including potential ecological effects. Various research communities view …
consequences including potential ecological effects. Various research communities view …
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
The elucidation of breast cancer subgroups and their molecular drivers requires integrated
views of the genome and transcriptome from representative numbers of patients. We present …
views of the genome and transcriptome from representative numbers of patients. We present …
Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illnesses
GA Bohach, DJ Fast, RD Nelson… - Critical reviews in …, 1990 - Taylor & Francis
Toxic-shock syndrome (TSS) is an acute onset, multiorgan illness which resembles severe
scarlet fever. The illness is caused by Staphylococcus aureus strains that express TSS toxin-1 …
scarlet fever. The illness is caused by Staphylococcus aureus strains that express TSS toxin-1 …
[PDF][PDF] Improved heritability estimation from genome-wide SNPs
… Using the weights defined by Equation 7 instead gave results intermediate between those
based on A and A* (results not shown, but follow from Figure S1D). Even if causal variants are …
based on A and A* (results not shown, but follow from Figure S1D). Even if causal variants are …
[HTML][HTML] Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast
… of chromosomes (0.1 kb–5,374 kb, see d). Horizontal dotted lines show the size of chromosome
… (d) Locations of SVs on the three chromosomes compared with other genomic features. …
… (d) Locations of SVs on the three chromosomes compared with other genomic features. …
Reevaluation of SNP heritability in complex human traits
… By way of demonstration, Supplementary Table 10 shows that model fit is improved by
assuming where D j is the distance (in kb) between SNP j and the nearest exon (under this model, …
assuming where D j is the distance (in kb) between SNP j and the nearest exon (under this model, …
[HTML][HTML] Graph pangenome captures missing heritability and empowers tomato breeding
… d, Comparison of genomic selection accuracies using SNPs and SVs as markers. The colour
scale indicates the estimated heritability contributed by SNPs. e, Comparison of genomic …
scale indicates the estimated heritability contributed by SNPs. e, Comparison of genomic …
Inactivation of faecal indicator micro-organisms in waste stabilisation ponds: interactions of environmental factors with sunlight
RJ Davies-Colley, AM Donnison, DJ Speed, CM Ross… - Water research, 1999 - Elsevier
Sunlight exposure is considered to be the most important cause of “natural” disinfection in
waste stabilisation ponds (WSPs). We examined the influence of dissolved oxygen (DO), pH, …
waste stabilisation ponds (WSPs). We examined the influence of dissolved oxygen (DO), pH, …
MultiBLUP: improved SNP-based prediction for complex traits
D Speed, DJ Balding - Genome research, 2014 - genome.cshlp.org
… ], and construct the diagonal matrix D with diagonal elements consisting of Graphic repeated
… and D is diagonal, the only inversion required is of the lower-dimensioned matrix (D −1 + Z…
… and D is diagonal, the only inversion required is of the lower-dimensioned matrix (D −1 + Z…