The antiarrhythmic effect of n-3 polyunsaturated fatty acids: modulation of cardiac ion channels as a potential mechanism
YF Xiao, DC Sigg, A Leaf - The Journal of membrane biology, 2005 - Springer
… (C), and 50 μM cocaine (D). Currents were elicited by 10-ms test pulses to 30 mV following
500-ms conditional … DHA at 10 μM had no significant effect on the I f reversal potential (D). …
500-ms conditional … DHA at 10 μM had no significant effect on the I f reversal potential (D). …
[PDF][PDF] Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel
SA Seoh, D Sigg, DM Papazian, F Bezanilla - neuron, 1996 - cell.com
The activation of Shaker K + channels is steeply voltage dependent. To determine whether
conserved charged amino acids in putative transmembrane segments S2, S3, and S4 …
conserved charged amino acids in putative transmembrane segments S2, S3, and S4 …
Quantum-enhanced advanced LIGO detectors in the era of gravitational-wave astronomy
The Laser Interferometer Gravitational Wave Observatory (LIGO) has been directly detecting
gravitational waves from compact binary mergers since 2015. We report on the first use of …
gravitational waves from compact binary mergers since 2015. We report on the first use of …
An all-optical trap for a gram-scale mirror
… In curves (b), (c), and (d), we detune the carrier by more than the cavity linewidth since the …
spring resonance becomes stable, shown in curve (d), allowing operation of the cavity without …
spring resonance becomes stable, shown in curve (d), allowing operation of the cavity without …
Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker
…, RH Anderson, R Billeter, V Sharma, DC Sigg… - Circulation, 2009 - Am Heart Assoc
Background— Although we know much about the molecular makeup of the sinus node (SN)
in small mammals, little is known about it in humans. The aims of the present study were to …
in small mammals, little is known about it in humans. The aims of the present study were to …
Modeling ion channels: Past, present, and future
D Sigg - Journal of General Physiology, 2014 - rupress.org
… Hence, if C → ∞, the doubly coupled scheme reduces to a two-state model described by
Z = 1 + LJ 4 (D/C) 4 , provided we also have a large D to maintain energy balance (note the …
Z = 1 + LJ 4 (D/C) 4 , provided we also have a large D to maintain energy balance (note the …
[HTML][HTML] Endogenous channels in HEK cells and potential roles in HCN ionic current measurements
…, EM TenBroek, J Coles Jr, DC Sigg - Progress in biophysics and …, 2006 - Elsevier
… The currents during the tail pulse are shown at a higher resolution in Panel D. Panel D: Tail
currents in panel C; the top trace is from the voltage pulse to −140 mV and the bottom traces …
currents in panel C; the top trace is from the voltage pulse to −140 mV and the bottom traces …
Optical dilution and feedback cooling of a gram-scale oscillator to 6.9 mK
We report on the use of a radiation pressure induced restoring force, the optical spring effect,
to optically dilute the mechanical damping of a 1 g suspended mirror, which is then cooled …
to optically dilute the mechanical damping of a 1 g suspended mirror, which is then cooled …
Identification and mitigation of narrow spectral artifacts that degrade searches for persistent gravitational waves in the first two observing runs of Advanced LIGO
…, L Sammut, S Schlassa, D Sigg, N Strauss, D Tao… - Physical Review D, 2018 - APS
Searches are under way in Advanced LIGO and Virgo data for persistent gravitational waves
from continuous sources, eg rapidly rotating galactic neutron stars, and stochastic sources, …
from continuous sources, eg rapidly rotating galactic neutron stars, and stochastic sources, …
Gravitational wave detector with cosmological reach
Twenty years ago, construction began on the Laser Interferometer Gravitational-wave
Observatory (LIGO). Advanced LIGO, with a factor of 10 better design sensitivity than Initial LIGO, …
Observatory (LIGO). Advanced LIGO, with a factor of 10 better design sensitivity than Initial LIGO, …