Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and
therapeutic resistance—involve complex interactions between cells within the dynamic tumor …

… license imaging mass cytometry technology from D. Günther represented by ETH Zürich,
which includes a related funded research collaboration benefiting the D. Günther and BB labs. …

Respiratory failure is the leading cause of death in patients with severe SARS-CoV-2
infection 1 , 2 , but the host response at the lung tissue level is poorly understood. Here we …

Conducted a meta-analysis of 143 outcome studies in which 2 or more treatments were
compared with a control group. Consistent with previous reviews, the mean of the 1,828 effect …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer.
Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform …

Although participants with psychiatric symptoms, specific risk factors, or rare demographic
characteristics can be difficult to identify and recruit for participation in research, participants …

Spatial and molecular characteristics determine tissue function, yet high-resolution methods
to capture both concurrently are lacking. Here, we developed high-definition spatial …

Combined PARP and immune checkpoint inhibition has yielded encouraging results in
ovarian cancer, but predictive biomarkers are lacking. We performed immunogenomic profiling …

Single-cell, spatially resolved omics analysis of tissues is poised to transform biomedical
research and clinical practice. We have developed an open-source, computational histology …

… Colours along the bottom correspond to the cell types in d. f, Uniform manifold approximation
and projection (UMAP) of snATAC-seq data for all samples (n = 46,068). g, Chromatin …