Platelets are small cells, 1/14th the volume of erythrocytes, and about 1000 billion circulate
in human blood as smooth anucleate disks. Their job is to survey the lining of our blood …

Animal models have contributed significantly to our understanding of the underlying biological
mechanisms of Alzheimer's disease (AD). As a result, over 300 interventions have been …

Apolipoprotein E is associated with age-related risk for Alzheimer's disease and plays
critical roles in Aβ homeostasis. We report that ApoE plays a role in facilitating the proteolytic …

Why should one study a worm? This simple creature is one of several “model” organisms that
together have provided tremendous insight into how all organisms are put together. It has …

To effect large system change, “niche” or local-level innovations must span spatial and
institutional scales to achieve broader systemic impact. Leaders of social innovation, in particular …

… ture form of Asp2 is associated with rafts (Figure 1a–d and Figure S2), suggesting that, in …
WX, (c) 1% (w/v) CHAPS, or (d) 500 mM sodium carbonate. These homogenates were then …

… c, d, The amount of apoE3 or apoE4 per allele was calculated for frontal cortex (c) and
hippocampus (d). The amount of apoE3 per allele is similar between ε3/3 and ε3/4 mice. …

Why do so many social innovations fail to have a broad impact? Successful social entrepreneurs
and nonprofit organizations often “scale out” innovative solutions to local problems in …

Recent studies show that intracellular cholesterol levels can modulate the processing of
amyloid precursor protein to Aβ peptide. Moreover, cholesterol-rich apoE-containing …

… In CSF and plasma (Figure 3c,d), the maximum reductions of Aβ 40 were 64% and 59%,
respectively, and were observed at the 1 h time point post dosing 30 mg/kg. The increase of Aβ …