… the cytokine IL-15 and vitamins A and D, further expand and adapt the natural IEL compartment.
In light of this, a recent study showed that vitamin D receptor (VDR)-deficient mice had …

Multidirectional interactions between the nervous and immune systems have been documented
in homeostasis and pathologies ranging from multiple sclerosis to autism, and from …

… (D) RORγt mRNA analyzed at various times by polymerase chain reaction in CD4 T cells
stimulated with anti-CD3ϵ and anti-CD28. Where indicated, IL-17–inducing cytokines (IL-17 …

… into plasma cells that produce large amounts of virus-specific secretory immunoglobin A (IgA)
antibodies that are translocated to the lumen where they can neutralize virus (Figure 2D). …

… Tumor size was also reduced (Figure 1C), and Il6À/À mice exhibited a higher frequency of
smaller adenomas than WT mice (Figure 1D). Correspondingly, average tumor load, a sum of …

… d–f, CPC-APC mice were treated with a cocktail of antibiotics (Abx) for 3 weeks. d,
Myeloid cells were sorted from tumours and analysed by RT–qPCR, representative of two …

… d–k, SPF mice were subjected to subcutaneous implantation of MC38 cells (d–j) or Braf
V600E Pten −/− melanoma cells (k), followed by repetitive oral dosing of 11- or 10-mix. Anti-PD-1 …

Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial
changes. It is tightly regulated by complex cellular interactions; however, our understanding of …

Mucosal tolerance prevents pathological reactions against environmental and food antigens,
and its failure results in exacerbated inflammation typical of allergies and asthma. One of …

… f8232.5-d locus where the CRISPR sequences were originally integrated, suggesting that
they originate from a double recombination event, one that removes the CRISPR sequences …