The role of selection in the evolution of human mitochondrial genomes

…, C Scharfe, A Torroni, R Scozzari, D Modiano… - Genetics, 2006 - academic.oup.com
… changes from and to threonine and valine differed significantly (P = 0.003) between populations
with neutral (22/58) and populations with significantly negative Tajima's D values (70/76)…

[HTML][HTML] Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

…, C Sutherland, C Roper, V Mangano, D Modiano… - Nature, 2012 - nature.com
… the genome, after correcting for population structure and other confounders, we find that r
2 decays to less than 0.1 within 1 kilobase (kb) in all populations studied here, whereas D′ …

Haemoglobin C protects against clinical Plasmodium falciparum malaria

D Modiano, G Luoni, BS Sirima, J Simporé, F Verra… - Nature, 2001 - nature.com
Haemoglobin C (HbC; β6Glu → Lys) is common in malarious areas of West Africa, especially
in Burkina Faso 1 , 2 . Conclusive evidence exists on the protective role against severe …

[HTML][HTML] Genome-wide and fine-resolution association analysis of malaria in West Africa

…, M Lemnge, J Makani, K Marsh, P Michon, D Modiano… - Nature …, 2009 - nature.com
We report a genome-wide association (GWA) study of severe malaria in The Gambia. The
initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a …

[PDF][PDF] A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes

…, V Macaulay, P Moral, A Olckers, D Modiano… - The American Journal of …, 2002 - cell.com
… For each network, the smallest circles represent a count of one individual, with the exception
of the network depicted in D (haplotype 24), where only haplotypes having an absolute …

Genetics of susceptibility to Plasmodium falciparum: from classical malaria resistance genes towards genome‐wide association studies

F Verra, VD Mangano, D Modiano - Parasite immunology, 2009 - Wiley Online Library
… David Modiano's research group was supported by the European Union Sixth Framework
Program BioMalPar Network of Excellence through grant LSHP-CT-2004-503578, and the …

Different response to Plasmodium falciparum malaria in West African sympatric ethnic groups

D Modiano, V Petrarca, BS Sirima… - Proceedings of the …, 1996 - National Acad Sciences
The comparison of malaria indicators among populations that have different genetic backgrounds
and are uniformly exposed to the same parasite strains is one approach to the study of …

[PDF][PDF] Chombo software package for AMR applications design document

…, TJ Ligocki, DF Martin, D Modiano… - Available at the …, 2009 - researchgate.net
In many problems in partial differential equations, one is confronted with problems having
multiple length scales and strong spatial localizations. Examples include nonlinear systems of …

A Cartesian grid embedded boundary method for hyperbolic conservation laws

P Colella, DT Graves, BJ Keen, D Modiano - Journal of Computational …, 2006 - Elsevier
… , ( i + 1 2 v ) h ] , i ∈ Z D , where D is the dimensionality of the problem, h is the mesh spacing,
… 1 2 e d which are the intersection of the boundary of ∂ V i with the coordinate planes { x : x …

Resistance to malaria through structural variation of red blood cell invasion receptors

…, EC Bougouma, VD Mangano, D Modiano… - Science, 2017 - science.org
INTRODUCTION Malaria parasites cause human disease by invading and replicating inside
red blood cells. In the case of Plasmodium falciparum, this can lead to severe forms of …