… c, d, Distribution of microbial dysbiosis scores as a measure of disease activity (c, median
Bray–Curtis dissimilarity between a sample and non-IBD samples; see Methods) and its …

The particularly interdisciplinary nature of human microbiome research makes the organization
and reporting of results spanning epidemiology, biology, bioinformatics, translational …

In this review, we provide an update on genome-wide association studies (GWAS) in
inflammatory bowel disease (IBD). In addition, we summarize progress in defining the functional …

Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS)
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …

Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…

Decreases in the diversity of enteric bacterial populations are observed in patients with
Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these …

The intestinal microflora, typically equated with bacteria, influences diseases such as obesity
and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich …

More than 1,000 susceptibility loci have been identified through genome-wide association
studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of …