The toxicogenomics field aims to understand and predict toxicity by using ‘omics’ data in order
to study systems-level responses to compound treatments. In recent years there has been …

Cancer is increasingly perceived as a systems-level, network phenomenon. The major
trend of malignant transformation can be described as a two-phase process, where an initial …

… elegans and D. melanogaster; 2) combines manual curation with large-scale datasets; 3) …
d) An interactive network of first neighbors is available, visualized by the CytoscapeWeb …

Molecular knowledge of biological processes is a cornerstone in omics data analysis. Applied
to single‐cell data, such analyses provide mechanistic insights into individual cells and …

NRF2 is a well-known, master transcription factor (TF) of oxidative and xenobiotic stress
responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing …

Autophagy is a complex cellular process having multiple roles, depending on tissue,
physiological, or pathological conditions. Major post-translational regulators of autophagy are well …

… However, at late stage primary or metastatic tumors, where the underlying network structures
became more asymmetric again (Dezső Módos, Katalin Lenti, Tamás Korcsmáros and …

… SignaLink3 is the largest signaling resource for D. melanogaster with over 1400 unique
proteins and 30 miRNAs. Next to D. melanogaster SignaLink is the only currently available …

NRF2 is the master transcriptional regulator of oxidative and xenobiotic stress responses.
NRF2 has important roles in carcinogenesis, inflammation, and neurodegenerative diseases. …

Pathway analysis is an informative method for comparing and contrasting drug-induced gene
expression in cellular systems. Here, we define the effects of the marine natural product …