… d Painting residuals after fitting optimal ancestral palettes using badMIXTURE, on the
residual scale shown. e Ancestral palettes estimated by badMIXTURE. 13 populations in total …

… d, Tumour cell types and states differ from normal tissue. Single-cell studies have shown
that tumours contain stem-like cells (CSCs) and that differentiation is often noisy, skewed …

Simple insights from the physics of ice, water and sediment place constraints on the possible
sediment-transport behavior of glaciers and ice sheets. Because glaciers concentrate runoff…

We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow
fever and dengue fever, which at ∼1376 million base pairs is about 5 times the size of the …

HIGH levels of speech recognition have been achieved with a new sound processing strategy
for multielectrode cochlear implants. A cochlear implant system consists of one or more …

Background Stimulating an immune response against cancer with the use of vaccines remains
a challenge. We hypothesized that combining a melanoma vaccine with interleukin-2, an …

Effective and targeted conservation action requires detailed information about species, their
distribution, systematics and ecology as well as the distribution of threat processes which …

… 3 c, d). Thus the exposure of the catalytic residues is accompanied by a marked increase
in the nonpolarity of the surrounding surface. Interfacial activation is thus explained by the …

Background Depression commonly complicates treatment with the cytokine interferon alfa-2b.
Laboratory animals pretreated with antidepressants have less severe depression-like …

Abstract Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) is associated with
an increased risk of peptic ulcer complications, but it is not clear whether some drugs are …