Many psychiatric disorders are characterized by circadian rhythm abnormalities, including
disturbed sleep/wake cycles, changes in locomotor activity, and abnormal endocrine function. …

Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep,
and appetite. Since many of these processes are regulated by circadian function, circadian …

… ::LUC rhythms in the absence of the SCN (Landgraf & Welsh, 2013). In contrast, … (D) Does
the rescue of WT Clock expression in the VTA of Clock-d19 mice … D-box binding protein (DBP) …

… (D) Rate of change of reporter concentration as a function of activator concentration for …
(D) The frequency distribution of RFP and YFP fluorescence intensities from single cells as …

We introduce a nonintrusive method exploiting single-cell variability after cell division to
validate protein localization. We found that Clp proteases, widely reported to form biologically …

In Parkinson's disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-rich
organ. We investigated how alterations in αS or lipid/fatty acid homeostasis affect each …

Background Major depressive disorder is associated with disturbed circadian rhythms. To
investigate the causal relationship between mood disorders and circadian clock disruption, …

Background Circadian clocks control cell cycle factors, and circadian disruption promotes
cancer. To address whether enhancing circadian rhythmicity in tumor cells affects cell cycle …

… C and D: clock gene expression profiles (C) and mRNA levels (D) of exocytosis genes at
ZT18 in pancreata from HFD-fed WT and Cry1/2 −/− mice (n = 3–5). *P < 0.05 relative to WT …

… (D) Trajectories from simulation of delayed autoinhibition that incorporate transcription
initiation bursts exhibit a broad distribution of period lengths (shown in E). (F) When simulations …