Both blood vessels and nerves are guided to their target. Vascular endothelial growth factor
(VEGF)A is a key signal in the induction of vessel growth (a process termed angiogenesis). …

… (156); the role of endogenous VEGF-D, even though capable of … No role for VEGF-D in the
nervous system is known thus far. … Likewise, VEGF-C and -D are known to bind heterodimers …

Bevacizumab is the first antiangiogenic therapy proven to slow metastatic disease progression
in patients with cancer. Although it has changed clinical practice, some patients do not …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

… (D) Kaplan-Meier estimates of the overall survival time (in weeks) are shown in the terminal
nodes. The tree shows that to best predict overall survival, KRAS mutations should be …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for ∼9…

Background In the Medical Research Council (MRC) COIN trial, the epidermal growth factor
receptor (EGFR)-targeted antibody cetuximab was added to standard chemotherapy in first-…

… To document whether a combination of PGF and VEGF would be more potent in stimulating
postischemic angiogenesis in vivo, we administered these ligands for 7 d after coronary …

Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human lung …