User profiles for D. Jachimowicz

Ron D. Jachimowicz

University of Cologne
Verified email at uk-koeln.de
Cited by 868

Highly parallel direct RNA sequencing on an array of nanopores

DR Garalde, EA Snell, D Jachimowicz, B Sipos… - Nature …, 2018 - nature.com
Sequencing the RNA in a biological sample can unlock a wealth of information, including
the identity of bacteria and viruses, the nuances of alternative splicing or the transcriptional …

Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma

…, PK Juvvuna, ST Kosalai, S Reischl, D Jachimowicz… - Cancer Research, 2021 - AACR
This study shows how a p53-responsive lncRNA mediates chemotherapeutic response by
modulating nuclear p53 pathways and identifies a potential treatment strategy for patients with …

LY6K-AS lncRNA is a lung adenocarcinoma prognostic biomarker and regulator of mitotic progression

MM Ali, M Di Marco, S Mahale, D Jachimowicz… - Oncogene, 2021 - nature.com
D Violin plot showing the expression levels of CTD-2292P10.4 (LY6K-AS) in healthy
human tissues. The Y-axis represents the normalized transcript per million (TPM) values. …

[HTML][HTML] Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia

…, J Weiss, A Schmitt, RD Jachimowicz… - Nature …, 2018 - nature.com
Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to
understand the mechanisms that lead to treatment resistance. To this end, we analyzed whole-…

DNA double-strand break repair pathway choice-from basic biology to clinical exploitation

RD Jachimowicz, J Goergens, HC Reinhardt - Cell Cycle, 2019 - Taylor & Francis
Mutations in genes encoding components of the DNA damage response (DDR) are among
the most frequent aberrations in human tumors. Moreover, a large array of human syndromes …

HOTAIR in relation to epithelial-mesenchymal transition and cancer stem cells in molecular subtypes of endometrial cancer

…, D Jachimowicz… - … journal of biological …, 2016 - journals.sagepub.com
Background Endometrial cancer (EC) is a hormone-related disease, showing highly diverse
features of ER/PR/HER2 status-based molecular subtypes. Long noncoding RNA (lncRNA) …

[PDF][PDF] UBQLN4 represses homologous recombination and is overexpressed in aggressive tumors

RD Jachimowicz, F Beleggia, J Isensee, BB Velpula… - Cell, 2019 - cell.com
Genomic instability can be a hallmark of both human genetic disease and cancer. We
identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome …

[HTML][HTML] Targeting DNA repair, cell cycle, and tumor microenvironment in B cell lymphoma

PJ Bröckelmann, MRW de Jong, RD Jachimowicz - Cells, 2020 - mdpi.com
The DNA double-strand break (DSB) is the most cytotoxic lesion and compromises genome
stability. In an attempt to efficiently repair DSBs, cells activate ATM kinase, which …

Baseline serum TARC levels predict therapy outcome in patients with Hodgkin lymphoma

…, RD Jachimowicz, D Kleefisch… - American journal of …, 2013 - Wiley Online Library
Hodgkin lymphoma (HL) has become one of the best curable cancers. However, better
biomarkers are needed for outcome prediction that would allow protecting patients from over‐ or …

METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma

…, A Djos, D Jachimowicz… - Nucleic Acids …, 2024 - academic.oup.com
Telomerase-negative tumors maintain telomere length by alternative lengthening of
telomeres (ALT), but the underlying mechanism behind ALT remains poorly understood. A …