Functional and structural inter-relationships of RNA and proteins in the execution and
control of biological processes such as RNA processing, RNA splicing, and translation are …

… and D-serine dehydratase, which catalyzes the physiological dehydratase reaction of D-serine,
both have sequence … of the Herschlag lab for helpful comments on the manuscript. …

Nucleic acid hairpins provide a powerful model system for understanding macromolecular
folding, with free-energy landscapes that can be readily manipulated by changing the hairpin …

Posttranscriptional processing of mRNA is an integral component of the gene expression
program. By using DNA microarrays, we precisely measured the decay of each yeast mRNA, …

We have analyzed the translational status of each mRNA in rapidly growing Saccharomyces
cerevisiae. mRNAs were separated by velocity sedimentation on a sucrose gradient, and …

… We thank Maitreya Dunham, Donna Storton, Joseph DeRisi, and Adam Carroll and members
of the Brown and Herschlag labs for advice and discussions. We appreciate comments on …

Using fluorescence microscopy, we studied the catalysis by and folding of individual
Tetrahymena thermophila ribozyme molecules . The dye-labeled and surface-immobilized …

Genes encoding RNA-binding proteins are diverse and abundant in eukaryotic genomes.
Although some have been shown to have roles in post-transcriptional regulation of the …

MicroRNAs (miRNAs) regulate gene expression posttranscriptionally by interfering with a
target mRNA's translation, stability, or both. We sought to dissect the respective contributions of …

Nucleic acid hairpins provide a powerful model system for probing the formation of secondary
structure. We report a systematic study of the kinetics and thermodynamics of the folding …