There is a growing recognition that gliomas are complex tumors composed of neoplastic and
non-neoplastic cells, which each individually contribute to cancer formation, progression …

Glioblastomas (glioblastoma multiforme, GBM) are one of the most recalcitrant brain tumors
because of their aggressive invasive growth and resistance to therapy. They are highly …

Glioblastomas (GBMs) are the most common and aggressive primary brain tumors. Due to
their malignant growth and invasion into the brain parenchyma coupled with resistance to …

In normal brain, the side population (SP) phenotype is generated by ABC transporter activity
and identifies stem cell and endothelial cell subpopulations by dye exclusion. By drug efflux…

… -associated microglia compared to naïve microglia (D), TAMs compared to naïve monocytes
(E… This work was also supported by NCI grants U01CA160882 (D. Hambardzumyan and DH …

… Finally, we demonstrate that miR-26a-mediated PTEN repression in a murine glioma model
both enhances de novo tumor formation and precludes loss of heterozygosity and the PTEN …

Background Glioblastoma multiforme (GBM) is an umbrella designation that includes a
heterogeneous group of primary brain tumors. Several classification strategies of GBM have …

eNOS expression is elevated in human glioblastomas and correlated with increased tumor
growth and aggressive character. We investigated the potential role of nitric oxide (NO) …

Medulloblastomas are brain tumors that arise in the cerebellum of children and contain stem
cells in a perivascular niche thought to give rise to recurrence following radiation. We used …

… (B–D) Bar graphs display the results of flow cytometric analysis of (B) Ly6Chi monocytes,
(C) total myeloid cells, and (D) microglia in brain homogenates of mice from the respective …