The harmful effects of inbreeding can be reduced if deleterious recessive alleles were
removed (purged) by selection against homozygotes in earlier generations. If only a few …

… copepods were treated with Primaxin (20 mg/L), d-amino acids to remove biofilm (10 µm
of d-methionine, d-leucine and d-tryptophan and 5 µm d-tyrosine), and Voriconazole (0.5 mg/L) …

… At time t= 0 we introduce a single novel mutant allele at a random one of the two loci: either
a derived allele (d) at the target locus or a plasticity modifier allele (M) at the modifier locus. …

Severity of inbreeding depression depends on the hidden (ie, recessive) genetic load carried
by a population. If the load is distributed unevenly among founder genomes, or founder-…

Under dominance, the relationship between a quantitative trait and the inbreeding coefficient
(F) is expected to be linear. Epistasis involving dominance effects or selection against …

… 1b, 2c,d) we recover balanced polymorphism at the plasticity locus even when migration
occurs very rarely, such as only once every 1000 generations. These results imply that isolated …

… with fitness of the derived (d) relative to that of ancestral (a) allele ( w d , t i / w a , t i ), with …
For example, consider a modification to our model where w d = 1+ s t + S (i) and w a = 1, with s …

… At time T d , the ancestral population splits into two daughter populations. They remain
diverged for T d generations without exchanging migrants. The effective size of the first population…

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… Therefore, we find an excess of a–a or d–d haplotypes compared to expectation—that is,
positive LD. Hence, genomic storage presents a naturally plausible mechanism for clustering of …