G-protein-coupled receptors (GPCRs) represent the major protein family for cellular modulation
in mammals. Therefore, various strategies have been developed to analyze the function …

Optogenetics uses light‐sensitive proteins, so‐called optogenetic tools, for highly precise
spatiotemporal control of cellular states and signals. The major limitations of such tools include …

Opn7b is a non-visual G protein-coupled receptor expressed in zebrafish. Here we find that
Opn7b expressed in HEK cells constitutively activates the G i/o pathway and illumination with …

The signal specificity of G protein-coupled receptors (GPCRs) including serotonin receptors
(5-HT-R) depends on the trafficking and localization of the GPCR within its subcellular …

Bioluminescence is a fascinating phenomenon and can be found in many different organisms
including fish. It has been suggested that bioluminescence is used for example for defense…

The primary goal of optogenetics is the light‐controlled noninvasive and specific manipulation
of various cellular processes. Herein, we present a hybrid strategy for targeted protein …

Optogenetics combines the use of light-sensitive proteins with genetic targeting strategies.
In recent years, the expanded optogenetic toolbox has broadened the understanding of cell …

… (D) Measure of the visual acuity by optokinetic re ex in rd10 mice injected with AAV-GIRK2-…
(D) Measure of the visual acuity by optokinetic re ex in huP347S+/- mice injected with AAV-…

The cover feature picture shows a structural model of the molecular light switch melanopsin
symbolically placed in a mouse brain. Light absorption of melanopsin activates signal …

… In more formal terms, we are interested in the posterior distribution (p(θ|D)) given the
likelihood of the data (p(D|θ)) and prior parameter probabilities (p(θ)). Bayes theorem states that …