User profiles for D. Durocher

Daniel Durocher

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and Department of …
Verified email at lunenfeld.ca
Cited by 31042

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

D Durocher, SP Jackson - Current opinion in cell biology, 2001 - Elsevier
… Thus, cells and animals deficient in DNA-PK are defective in DSB repair and in V(D)J
recombination, a process by which antibody and T-cell receptor diversity is generated, and are …

The control of DNA repair by the cell cycle

N Hustedt, D Durocher - Nature cell biology, 2017 - nature.com
… Extended D-loops can be directly unwound by helicases followed by ligation in a process
termed synthesis-dependent strand annealing (SDSA) 9 . Alternatively, when both ends …

[PDF][PDF] Regulation of DNA damage responses by ubiquitin and SUMO

SP Jackson, D Durocher - Molecular cell, 2013 - cell.com
Ubiquitylation and sumoylation, the covalent attachment of the polypeptides ubiquitin and
SUMO, respectively, to target proteins, are pervasive mechanisms for controlling cellular …

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

…, D Durocher, M Mann, CWV Hogue, D Figeys… - Nature, 2002 - nature.com
The recent abundance of genome sequence data has brought an urgent need for systematic
proteomics to decipher the encoded protein networks that dictate cellular function 1 . To …

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

…, ZY Lin, BG Badillo, T Pawson, D Durocher… - Nature …, 2013 - nature.com
Affinity purification coupled with mass spectrometry (AP-MS) is a widely used approach for
the identification of protein-protein interactions. However, for any given protein of interest, …

[PDF][PDF] A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

…, M Munro, MD Canny, D Xu, D Durocher - Molecular cell, 2013 - cell.com
DNA double-strand break (DSB) repair pathway choice is governed by the opposing activities
of 53BP1 and BRCA1. 53BP1 stimulates nonhomologous end joining (NHEJ), whereas …

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

…, TM Thomson, L Pelletier, SP Jackson, D Durocher - Science, 2007 - science.org
Cells respond to DNA double-strand breaks by recruiting factors such as the DNA-damage
mediator protein MDC1, the p53-binding protein 1 (53BP1), and the breast cancer …

[HTML][HTML] RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

…, R Pepperkok, J Ellenberg, S Panier, D Durocher… - Cell, 2009 - cell.com
… a very similar level as the wild-type protein (Figure S6A), accumulated poorly and was
significantly impaired in generating ubiquitin conjugates at the DSB-flanking chromatin (Figure 3D)…

[HTML][HTML] High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities

…, P Dirks, S Sidhu, FP Roth, OS Rissland, D Durocher… - Cell, 2015 - cell.com
The ability to perturb genes in human cells is crucial for elucidating gene function and holds
great potential for finding therapeutic targets for diseases such as cancer. To extend the …

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

…, SM Noordermeer, F Sicheri, D Durocher - Nature, 2013 - nature.com
53BP1 (also called TP53BP1) is a chromatin-associated factor that promotes immunoglobulin
class switching and DNA double-strand-break (DSB) repair by non-homologous end …