[PDF][PDF] Extracellular vesicle and particle biomarkers define multiple human cancers

…, EK Slotkin, S Modak, SS Roberts, EM Basu, D Diolaiti… - Cell, 2020 - cell.com
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection.
We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in …

Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis

D Diolaiti, L McFerrin, PA Carroll… - Biochimica et Biophysica …, 2015 - Elsevier
The transcription factor MYC and its related family members MYCN and MYCL have been
implicated in the etiology of a wide spectrum of human cancers. Compared to other …

[PDF][PDF] Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis

PA Carroll, D Diolaiti, L McFerrin, H Gu, D Djukovic… - Cancer cell, 2015 - cell.com
Deregulated Myc transcriptionally reprograms cell metabolism to promote neoplasia. Here
we show that oncogenic Myc requires the Myc superfamily member MondoA, a nutrient-…

A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors

…, PA Clemons, FS Dela Cruz, D Dhall, D Diolaiti… - Nature …, 2018 - nature.com
We introduce and validate a new precision oncology framework for the systematic prioritization
of drugs targeting mechanistic tumor dependencies in individual patients. Compounds …

[HTML][HTML] Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations

…, H Remotti, RJ Zylber, J Pang, D Diolaiti… - Genome medicine, 2016 - Springer
Background Molecular characterization has the potential to advance the management of
pediatric cancer and high-risk hematologic disease. The clinical integration of genome …

Changes in H2A. Z occupancy and DNA methylation during B-cell lymphomagenesis

ML Conerly, SS Teves, D Diolaiti, M Ulrich… - Genome …, 2010 - genome.cshlp.org
The histone variant H2A.Z has been implicated in the regulation of gene expression, and in
plants antagonizes DNA methylation. Here, we ask whether a similar relationship exists in …

In vivo transcriptional regulation of N-Myc target genes is controlled by E-box methylation

G Perini, D Diolaiti, A Porro… - Proceedings of the …, 2005 - National Acad Sciences
N-Myc is a transcription factor that forms heterodimers with the protein Max and binds gene
promoters by recognizing a DNA sequence, CACGTG, called E-box. The identification of N-…

[HTML][HTML] Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect …

A Porro, M Haber, D Diolaiti, N Iraci… - Journal of Biological …, 2010 - ASBMB
Increased expression of specific ATP-binding cassette (ABC) transporters is known to mediate
the efflux of chemotherapeutic agents from cancer cells. Therefore, establishing how ABC …

Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis

…, M Haber, MD Norris, D Diolaiti… - Proceedings of the …, 2007 - National Acad Sciences
Histone deacetylase (HDAC) inhibitors reactivate tumor suppressor gene transcription; induce
cancer cell differentiation, growth arrest, and programmed cell death; and are among the …

A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell …

N Iraci, D Diolaiti, A Papa, A Porro, E Valli, S Gherardi… - Cancer research, 2011 - AACR
Neuroblastoma is the most common extracranial solid tumor of childhood. One important
factor that predicts a favorable prognosis is the robust expression of the TRKA and p75NTR …