Background : Levels of atherogenic lipoproteins achieved with statin therapy are highly
variable, but the consequence of this variability for cardiovascular disease risk is not well-…

… This would be true only if activation had no effect on binding, which is not true for any
currently proposed mechanism of agonist action (Colquhoun, 1987). The problem of …

An Expert Working Group of the National Heart Foundation of Australia undertook a review
of systematic reviews of the evidence relating to major psychosocial risk factors to assess …

… of D, ie the probability of observing the set of symptoms S if a patient in fact has disease D,
P[S|D], could also be found from records of the proportion of patients with D showing the …

ATP is known to depolarize sensory neurons, and may play a role in nociceptor activation
when released from damaged tissue 1-10 . Here we report the molecular cloning and …

The aims of analysis of single-channel records can be considered in two categories. The first
is to allow one to observe results at leisure in order to determine their qualitative features. It …

Background Chronic hepatitis C virus (HCV) infection is a cause of major complications in
persons who are also infected with the human immunodeficiency virus (HIV). However, the …

UNTIL now, the only well documented, fast excitatory neurotrans-mitter in the brain has been
glutamate. Although there is evidence for adenosine 5′-triphosphate (ATP) acting as a …

… significance, though they can be interpreted by the more elaborate methods of AG Hawkes
& D. Colquhoun (in preparation). In order to circumvent this problem it was suggested that a …

… (see also: Neher & Steinbach 1978; Colquhoun 1981). A problem arises when there is more
… Colquhoun, D. 1981 Effects of antagonists on the kinetics of currents that flow through drug-…