Biased codon usage in protein-coding genes is pervasive, whereby amino acids are largely
encoded by a specific subset of possible codons. Within individual genes, codon bias is …

Bacterial genomes exhibit a large amount of variation in their base composition, which ranges
from 13% to 75% GC. The evolution and maintenance of this variation has proved to be …

… previously (“corn populations” in Agashe 2009). Therefore, here we only summarize key
elements of the experimental design; further details can be found in Agashe (2009). We initiated …

… (D. Agashe, unpublished data) and survivorship is lower (Table 1). As population size
increased and wheat became a limiting resource, niche variation could maintain different alleles in …

Evolution has traditionally been a historical and descriptive science, and predicting future
evolutionary processes has long been considered impossible. However, evolutionary …

Contrary to previous understanding, recent evidence indicates that synonymous codon
changes may sometimes face strong selection. However, it remains difficult to generalize the …

Age-related diseases are often attributed to immunopathology, which results in self-damage
caused by an inappropriate inflammatory response. Immunopathology associated with early-…

Theory and empirical evidence show that intraspecific competition can drive selection
favouring the use of novel resources (ie niche expansion). The evolutionary response to such …

Biased mutation spectra are pervasive, with wide variation in the magnitude of mutational
biases that influence genome evolution and adaptation. How do such diverse biases evolve? …

… We thank Agashe lab members for their constructive comments on the manuscript; Arun
Prakash, Jagrithi Ramnathan, Jagath Vedamurthy and Sanah Imani for laboratory assistance; …