A growing and interdisciplinary translational neuroscience research effort for neurodevelopmental
disorders (NDDs) is investigating the mechanisms of dysfunction and testing effective …

… on the reliability of this subset of probes (BH Mecham, DZ Wetmore, Z. Szallasi, Y. Sadovsky,
I. … number of unreliable sequences (BH Mecham, DZ Wetmore, Z. Szallasi, Y. Sadovsky, I. …

Down syndrome is characterized by mild to moderate cognitive impairments that are caused
by trisomy of chromosome 21. Several anatomical, behavioral, electrophysiological, and …

We engineered a transdermal neuromodulation approach that targets peripheral (cranial and
spinal) nerves and utilizes their afferent pathways as signaling conduits to influence brain …

Background and Purpose D own's syndrome is a common genetic cause of intellectual
disability, for which there are no drug therapies. Mechanistic studies in a model of D own's …

Many forms of learning require temporally ordered stimuli. In Pavlovian eyeblink conditioning,
a conditioned stimulus (CS) must precede the unconditioned stimulus (US) by at least …

Objective. Neural interfaces need to become more unobtrusive and socially acceptable to
appeal to general consumers outside rehabilitation settings. Approach. We developed a non-…

The cerebellar cortex is necessary for adaptively timed conditioned responses (CRs) in
eyeblink conditioning. During conditioning, Purkinje cells acquire pause responses or “Purkinje …

Microarrays have been extensively used to investigate genome-wide expression patterns.
Although this technology has been tremendously successful, it has suffered from suboptimal …

A basic question for theories of learning and memory is whether neuronal plasticity suffices
to guide proper memory recall. Alternatively, information processing that is additional to …