Examination of the effects of arsenic on glucose homeostasis in cell culture and animal studies: development of a mouse model for arsenic-induced diabetes
DS Paul, A Hernández-Zavala, FS Walton… - Toxicology and applied …, 2007 - Elsevier
Previous epidemiologic studies found increased prevalences of type 2 diabetes mellitus in
populations exposed to high levels of inorganic arsenic (iAs) in drinking water. Although …
populations exposed to high levels of inorganic arsenic (iAs) in drinking water. Although …
Metabolism of arsenic in human liver: the role of membrane transporters
Z Drobná, FS Walton, DS Paul, W Xing, DJ Thomas… - Archives of …, 2010 - Springer
Metabolism of inorganic arsenic (iAs) is one of the key factors determining the character of
adverse effects associated with exposure to iAs. Results of previous studies indicate that liver …
adverse effects associated with exposure to iAs. Results of previous studies indicate that liver …
[HTML][HTML] FinnGen provides genetic insights from a well-phenotyped isolated population
Population isolates such as those in Finland benefit genetic research because deleterious
alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor …
alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor …
[HTML][HTML] A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis
…, E Sørensen, GH Halldorsson, DS Paul… - Communications …, 2021 - nature.com
Iron is essential for many biological functions and iron deficiency and overload have major
health implications. We performed a meta-analysis of three genome-wide association studies …
health implications. We performed a meta-analysis of three genome-wide association studies …
Genomic atlas of the human plasma proteome
Although plasma proteins have important roles in biological processes and are the direct
targets of many drugs, the genetic factors that control inter-individual variation in plasma …
targets of many drugs, the genetic factors that control inter-individual variation in plasma …
[HTML][HTML] Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies
Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …
different national guidelines. To define thresholds associated with lowest risk for all-cause …
[PDF][PDF] The allelic landscape of human blood cell trait variation and links to common complex disease
Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …
causal genes and pathways has proven challenging. We performed a genome-wide …
FinnGen: Unique genetic insights from combining isolated population and national health register data
Population isolates such as Finland provide benefits in genetic studies because the allelic
spectrum of damaging alleles in any gene is often concentrated on a small number of low-…
spectrum of damaging alleles in any gene is often concentrated on a small number of low-…
PhenoScanner: a database of human genotype–phenotype associations
PhenoScanner is a curated database of publicly available results from large-scale genetic
association studies. This tool aims to facilitate ‘phenome scans’, the cross-referencing of …
association studies. This tool aims to facilitate ‘phenome scans’, the cross-referencing of …
[HTML][HTML] Genetic drivers of epigenetic and transcriptional variation in human immune cells
…, JHA Martens, WH Ouwehand, TW Kuijpers, DS Paul… - Cell, 2016 - cell.com
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high-…
phenotypes is a major challenge in human genetics and medicine. We carried out high-…