User profiles for D. S. Paul

Dirk S. Paul

- Verified email at medschl.cam.ac.uk - Cited by 11311

David S. Paul

- Verified email at med.unc.edu - Cited by 2531

Examination of the effects of arsenic on glucose homeostasis in cell culture and animal studies: development of a mouse model for arsenic-induced diabetes

DS Paul, A Hernández-Zavala, FS Walton… - Toxicology and applied …, 2007 - Elsevier
Previous epidemiologic studies found increased prevalences of type 2 diabetes mellitus in
populations exposed to high levels of inorganic arsenic (iAs) in drinking water. Although …

Metabolism of arsenic in human liver: the role of membrane transporters

Z Drobná, FS Walton, DS Paul, W Xing, DJ Thomas… - Archives of …, 2010 - Springer
Metabolism of inorganic arsenic (iAs) is one of the key factors determining the character of
adverse effects associated with exposure to iAs. Results of previous studies indicate that liver …

[HTML][HTML] FinnGen provides genetic insights from a well-phenotyped isolated population

…, HM Ollila, A Palomäki, T Palotie, J Partanen, DS Paul… - Nature, 2023 - nature.com
Population isolates such as those in Finland benefit genetic research because deleterious
alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor …

[HTML][HTML] A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

…, E Sørensen, GH Halldorsson, DS Paul… - Communications …, 2021 - nature.com
Iron is essential for many biological functions and iron deficiency and overload have major
health implications. We performed a meta-analysis of three genome-wide association studies …

Genomic atlas of the human plasma proteome

…, JA Todd, N Soranzo, K Suhre, DS Paul… - Nature, 2018 - nature.com
Although plasma proteins have important roles in biological processes and are the direct
targets of many drugs, the genetic factors that control inter-individual variation in plasma …

[HTML][HTML] Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

…, P Willeit, S Warnakula, T Bolton, E Paige, DS Paul… - The Lancet, 2018 - thelancet.com
Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …

[PDF][PDF] The allelic landscape of human blood cell trait variation and links to common complex disease

…, S Watt, Y Yang, R Guigo, S Beck, DS Paul… - Cell, 2016 - cell.com
Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

FinnGen: Unique genetic insights from combining isolated population and national health register data

…, HM Ollila, A Palomäki, T Palotie, J Partanen, DS Paul… - MedRxiv, 2022 - medrxiv.org
Population isolates such as Finland provide benefits in genetic studies because the allelic
spectrum of damaging alleles in any gene is often concentrated on a small number of low-…

PhenoScanner: a database of human genotype–phenotype associations

…, S Ellis, P Surendran, BB Sun, DS Paul… - …, 2016 - academic.oup.com
PhenoScanner is a curated database of publicly available results from large-scale genetic
association studies. This tool aims to facilitate ‘phenome scans’, the cross-referencing of …

[HTML][HTML] Genetic drivers of epigenetic and transcriptional variation in human immune cells

…, JHA Martens, WH Ouwehand, TW Kuijpers, DS Paul… - Cell, 2016 - cell.com
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high-…