Thrombotic thrombocytopenic purpura (TTP) is a life-threatening systemic illness of abrupt
onset and unknown cause. Proteolysis of the blood-clotting protein von Willebrand factor (VWF…

Primary pulmonary hypertension (PPH)f an often fatal disease, is characterized by elevated
pulmonary artery pressures in the absence of a secondary cause1. Endovascular occlusion …

Endothelial cells (ECs) are highly specialized across vascular beds. However, given their
interspersed anatomic distribution, comprehensive characterization of the molecular basis for …

We have determined the nucleotide sequence of the human plasminogen activator inhibitor-1
(PAI-1) gene and significant stretches of DNA which extend into its 5′-and 3′-flanking …

Combined Factors V and VIII deficiency is an autosomal recessive bleeding disorder identified
in at least 58 families comprising a number of different ethnic groups. Affected patients …

The 3′-terminal genomic regions of an isolate of watermelon mosaic virus II (WMVII) and a
Florida isolate of zucchini yellow mosaic virus (ZYMV-F) have been cloned. The nucleotide …

Recently, the preparation of dimeric molecules containing two of the DNA-alkylating cyclopropa
[c] pyrrolo [3, 2-e] indol-4-(5//)-one (CPI) subunits of CC-1065 was reported by these …

Mismatch between bone marrow transplant (BMT) patient and donor for an amino acid
polymorphism within the adhesion molecule CD31 has recently been reported to increase risk for …

… readings in the range of 800 hp can routinely be obtained (Siemieniak et at, 1991). … ATP
and [oi-“P]dC'I‘P, as described by Siemieniak et al. (1991). The ratio of ddNTP:dNTP was …

The serine protease inhibitor (SERPIN) plasminogen activator inhibitor-1 (PAI-1) is a key
regulator of the fibrinolytic system, inhibiting the serine proteases tissue- and urokinase-type …