User profiles for D. R. Shook

David R Shook

- Verified email at virginia.edu - Cited by 2997

David Shook

- Verified email at ucsf.edu - Cited by 1646

How we are shaped: the biomechanics of gastrulation

R Keller, LA Davidson, DR Shook - Differentiation: original …, 2003 - Wiley Online Library
Although it is rarely considered so in modern developmental biology, morphogenesis is
fundamentally a biomechanical process, and this is especially true of one of the first major …

Cytotoxicity of activated natural killer cells against pediatric solid tumors

D Cho, DR Shook, N Shimasaki, YH Chang… - Clinical Cancer …, 2010 - AACR
Purpose: To develop new therapies for children with solid tumors, we tested the cytotoxicity
of natural killer (NK) cells expanded by coculture with K562-mb15-41BBL cells. We sought to …

Epithelial type, ingression, blastopore architecture and the evolution of chordate mesoderm morphogenesis

DR Shook, R Keller - Journal of Experimental Zoology Part B …, 2008 - Wiley Online Library
… In the companion review (Shook and Keller, 2007), we focus on questions about the … (Shook
and Keller, unpublished data; Purcell and Keller, ’93; Minsuk and Keller, ’96, ’97; …

[HTML][HTML] Long-term outcome and evaluation of organ function in pediatric patients undergoing haploidentical and matched related hematopoietic cell transplantation …

MH Dallas, B Triplett, DR Shook, C Hartford… - Biology of Blood and …, 2013 - Elsevier
HLA-matched related donor (MRD) hematopoietic stem cell transplantation (HSCT) is a well-established
therapy for patients with sickle cell disease (SCD); however, experience using …

[HTML][HTML] Pattern and morphogenesis of presumptive superficial mesoderm in two closely related species, Xenopus laevis and Xenopus tropicalis

DR Shook, C Majer, R Keller - Developmental biology, 2004 - Elsevier
The mesoderm, comprising the tissues that come to lie entirely in the deep layer, originates
in both the superficial epithelial and the deep mesenchymal layers of the early amphibian …

[PDF][PDF] Mechanical strain determines the axis of planar polarity in ciliated epithelia

YH Chien, R Keller, C Kintner, DR Shook - Current Biology, 2015 - cell.com
Epithelia containing multiciliated cells align beating cilia along a common planar axis specified
by the conserved planar cell polarity (PCP) pathway. Specification of the planar axis is …

Rapid memory T-cell reconstitution recapitulating CD45RA-depleted haploidentical transplant graft content in patients with hematologic malignancies

BM Triplett, DR Shook, P Eldridge, Y Li… - Bone marrow …, 2015 - nature.com
T-cell depletion of an HLA-haploidentical graft is often used to prevent GVHD, but the
procedure may lead to increased graft failure, relapse and infections due to delayed immune …

[HTML][HTML] Longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell …

…, W Chemaitilly, BM Triplett, DR Shook… - Journal of clinical …, 2012 - ncbi.nlm.nih.gov
Purpose To measure longitudinal changes in body mass and composition in survivors of
childhood hematologic malignancies after allogeneic hematopoietic stem-cell …

Natural killer cell engineering for cellular therapy of cancer

DR Shook, D Campana - Tissue antigens, 2011 - Wiley Online Library
Natural killer (NK) cells can kill transformed cells and represent a promising tool for the
treatment of cancer. Their function is governed by a balance of stimulatory and inhibitory signals …

Selective T‐cell depletion targeting CD 45 RA reduces viremia and enhances early T‐cell recovery compared with CD 3‐targeted T‐cell depletion

…, W Janssen, E Mamcarz, DR Shook… - Transplant Infectious …, 2018 - Wiley Online Library
Background T‐cell depletion ( TCD ) effectively reduces severe graft‐versus‐host disease
in recipients of HLA ‐mismatched allografts. However, TCD is associated with delayed …