User profiles for D. R. Nyholt

Dale R Nyholt

Professor of Biomedical Sciences, Queensland University of Technology
Verified email at qut.edu.au
Cited by 63338

Analysis of shared heritability in common disorders of the brain

…, N Eriksson, J Olesen, DI Chasman, DR Nyholt… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets

N Rahmioglu, DR Nyholt, AP Morris… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND Endometriosis is a heritable common gynaecological condition influenced
by multiple genetic and environmental factors. Genome-wide association studies (GWASs) …

The search for genes contributing to endometriosis risk

GW Montgomery, DR Nyholt, ZZ Zhao… - Human reproduction …, 2008 - academic.oup.com
BACKGROUND Genetic variation contributes to the risk of developing endometriosis. This
review summarizes gene mapping studies in endometriosis and the prospects of finding gene …

Common SNPs explain a large proportion of the heritability for human height

…, BP McEvoy, S Gordon, AK Henders, DR Nyholt… - Nature …, 2010 - nature.com
… Dale R Nyholt … Jian Yang, Beben Benyamin, Brian P McEvoy, Scott Gordon, Anjali K Henders,
Dale R Nyholt, Nicholas G Martin, Grant W Montgomery & Peter M Visscher … Dale R Nyholt

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

…, N Mullins, M Nauck, B Ng, MG Nivard, DR Nyholt… - Nature …, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Hundreds of variants clustered in genomic loci and biological pathways affect human height

…, BF Voight, F Wiklund, J Xu, J Hua Zhao, DR Nyholt… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

[PDF][PDF] A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other

DR Nyholt - The American Journal of Human Genetics, 2004 - cell.com
… Address for correspondence and reprints: Dr. Dale R. Nyholt, Queensland Institute of
Medical Research, Post Office Royal Brisbane Hospital, Brisbane QLD 4029, Australia. E-mail: …

Defining the role of common variation in the genomic and biological architecture of adult human height

…, IM Leach, C Medina-Gomez, MA Nalls, DR Nyholt… - Nature …, 2014 - nature.com
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …

Genome-wide association study identifies 74 loci associated with educational attainment

…, GW Montgomery, R Myhre, CP Nelson, DR Nyholt… - Nature, 2016 - nature.com
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

…, ME Goddard, G Lettre, M Mangino, DR Nyholt… - Nature …, 2010 - nature.com
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …