Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

Genetic variants that inactivate protein-coding genes are a powerful source of information
about the phenotypic consequences of gene disruption: genes that are crucial for the function …

Genetic variants that inactivate protein-coding genes are a powerful source of information
about the phenotypic consequences of gene disruption: genes critical for an organism’s …

The clinical interpretation of genetic variants has come to rely heavily on reference population
databases such as the Exome Aggregation Consortium (ExAC) database. Pathogenic …

In this Article, author Marquis P. Vawter was missing from the Genome Aggregation
Database Consortium list. They are associated with the affiliation:‘Department of Psychiatry & …

Databases of human population genetic variation, such as the Genome Aggregation Database
(gnomAD), are generally expected to be depleted for variation with severe effects on …

Bacterial cellulose (BC) has excellent material properties and can be produced sustainably
through simple bacterial culture, but BC‐producing bacteria lack the extensive genetic …

Curli are amyloid proteins that are assembled into extracellular polymeric fibers by bacteria
during biofilm formation. The beta-sheet-rich protein CsgA, the primary structural component …

Many of the sequenced bacterial and archaeal genomes encode regions of viral provenance.
Yet, not all of these regions encode bona fide viruses. Gene transfer agents (GTAs) are …

Wastewater surveillance is a proven method for tracking community spread and prevalence
of some infectious viral diseases. A primary concentration step is often used to enrich viral …