We describe a new computer program, SnpEff, for rapidly categorizing the effects of variants
in genome sequences. Once a genome is sequenced, SnpEff annotates variants based on …

This paper describes a new program SnpSift for filtering differential DNA sequence variants
between two or more experimental genomes after genotoxic chemical exposure. Here, we …

The obesity epidemic is a global issue and shows no signs of abating, while the cause of
this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally-…

Morphological alterations have been shown to occur in Drosophila melanogaster when
function of Hsp90 (heat shock 90-kDa protein 1α, encoded by Hsp83) is compromised during …

It is conceivable that toxic metals contribute to obesity by influencing various aspects of
metabolism, such as by substituting for essential micronutrients and vital metals, or by inducing …

Amyotrophic lateral sclerosis (ALS) is a terminal disease involving the progressive degeneration
of motor neurons within the motor cortex, brainstem and spinal cord. Most cases are …

Phthalates are esters of phthalic acid which are used in cosmetics and other daily personal
care products. They are also used in polyvinyl chloride (PVC) plastics to increase durability …

Many environmental toxins, such as heavy metals, air particles, and ozone, induce oxidative
stress and decrease the levels of NADH and NADPH, cofactors that drive anabolic …

We report that the DNA methylation profile of a child’s neonatal whole blood can be
significantly influenced by his or her mother’s neonatal blood lead levels (BLL). We recruited 35 …

DNA methylation can regulate gene expression and has been shown to modulate cancer
cell biology and chemotherapy resistance. Therapeutic radiation results in a biological …