purpose. Retinal ganglion cell (RGC) death in glaucoma involves apoptosis. Activation of
caspases and abnormal processing of amyloid precursor protein (APP) are important events in …

Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with …

… Prevalence and distribution of type 2 diabetes mellitus in Mexican adult population. …
Prevalence and distribution of type 2 diabetes mellitus in Mexican adult population. …

… States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I.
… N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians. …

Gene therapy represents an attractive approach for the treatment of eye diseases such as
glaucoma. Ocular administration of viral vectors produces localized retinal gene expression …

TCF7L2 acts as both a repressor and transactivator of genes, as directed by the Wnt signaling
pathway. Recently, several highly correlated sequence variants located within a haplotype …

… BIR): a meta-analysis suggests a role in the polygenic basis of type II diabetes mellitus in …
States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An …

Hundreds of thousands of genetic variants have been reported to cause severe monogenic
diseases, but the probability that a variant carrier develops the disease (termed penetrance) …

… Donna M Lehman , Donna M Lehman … Linkage of type 2 diabetes mellitus and of age
at onset to a genetic location on chromosome 10q in Mexican Americans. …

Identity-by-descent (IBD) segments are a useful tool for applications ranging from demographic
inference to relationship classification, but most detection methods rely on phasing …