Across a variety of Mendelian disorders, ∼50–75% of patients do not receive a genetic
diagnosis by exome sequencing indicating disease-causing variants in non-coding regions. …

To investigate molecular mechanisms controlling islet vascularization and revascularization
after transplantation, we examined pancreatic expression of three families of angiogenic …

Most internal organs are situated in a coelomic cavity and are covered by a mesothelium.
During heart development, epicardial cells (a mesothelium) move to and over the heart, …

… Also, we thank members of the Mikawa and Bader laboratories for their critical reading of
the manuscript and Brian Robertson for his assistance in preparing the figures. …

A long and productive history in biomedical research defines the chick as a model for
human biology. Fundamental discoveries, including the description of directional circulation …

RNA sequencing (RNA-seq) is gaining popularity as a complementary assay to genome
sequencing for precisely identifying the molecular causes of rare disorders. A powerful …

Acute liver failure (ALF) in infancy and childhood is a life-threatening emergency. Few conditions
are known to cause recurrent acute liver failure (RALF), and in about 50% of cases, the …

Microarray technologies are established approaches for high throughput gene expression,
methylation and genotyping analysis. An accurate mapping of the array probes is essential to …

Background Mutations in microtubule-regulating genes are associated with disorders of
neuronal migration and microcephaly. Regulation of centriole length has been shown to …

Recent work has demonstrated the importance of the epicardium in the development of the
heart. During embryogenesis, these epithelial cells provide the progenitors for the epicardium…