Serotonin is a monoamine neurotransmitter, which is phylogenetically conserved in a wide
range of species from nematodes to humans. In mammals, age-related changes in serotonin …

The quest to extend healthspan via pharmacological means is becoming increasingly urgent,
both from a health and economic perspective. Here we show that lithium, a drug approved …

Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for
the prevention of neurodegenerative diseases, including Alzheimer’s disease (AD). Current …

We used 197 Drosophila melanogaster Genetic Reference Panel (DGRP) lines to perform a
genome-wide association analysis for virgin female lifespan, using ~2M common single …

Alzheimer’s disease is a neurodegenerative disorder and the most common form of dementia.
Early diagnosis may assist interventions to delay onset and reduce the progression rate of …

Polygenic risk scores (PRS) have been widely adopted as a tool for measuring common
variant liability and they have been shown to predict lifetime risk of Alzheimer’s disease (AD) …

Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet
the underlying biology remains unclear. We show that the anti-aging effects of rapamycin …

Many increasingly prevalent diseases share a common risk factor: age. However, little is
known about pharmaceutical interventions against aging, despite many genes and pathways …

Si/SiO 2 /Ni nanostructures are fabricated by the irradiation of an oxidized Si surface with
swift heavy ions, nanopore etching in the SiO 2 layer, and the electrochemical deposition of …

Reduced activity of insulin/insulin-like growth factor signaling (IIS) increases healthy lifespan
among diverse animal species. Downstream of IIS, multiple evolutionarily conserved …