There is increasing recognition that exposures to infectious agents evoke fundamental effects
on the development and behaviour of the immune system. Moreover, where infections (…

Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of
multiple genetic and environmental risk factors. We report the findings of a genome-wide …

Background Vitamin D is crucial for maintenance of musculoskeletal health, and might also
have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D …

The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA)
scan 1 on seven diseases, including the multifactorial autoimmune disease type 1 …

Background Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in
populations, suggesting a common genetic origin. Since both diseases are associated with …

Helminth parasitic infections are a major global health and social burden 1 . The host
defence against helminths such as Nippostrongylus brasiliensis is orchestrated by type 2 cell-…

In this study we report convincing statistical support for a sixth type 1 diabetes (T1D) locus in
the innate immunity viral RNA receptor gene region IFIH1 (also known as mda-5 or Helicard…

The main problems in drawing causal inferences from epidemiological case-control studies
are confounding by unmeasured extraneous factors, selection bias and differential …

We carried out a meta-analysis of data from three genome-wide association (GWA) studies
of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of …

… DJS and RB contributed to SNP discovery and genotyping, KB contributed to the plasma
sIL-2RA study. SF contributed to the genotyping. VP and DGC contributed to data analysis. …